EXPLAINER: Lab results and their interpretation

What is the result for your surface antibody test? False positive results are possible too. I empathize with you.

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In February (two tests) it varied from 0.5 to 1.5. On this last test in June (which I think is positive), it was around 3.1. Both are under the threshold of 10. Which is odd because I had two twin-rex vaccines and followed it by a recombinex or whatever it was called, back in 2004/2005.

Thank you.

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So, your surface antigen test is not accurate. You do have antibiotics but not very high. You might want to consider a new test for surface antigen, viral load and if those are negative then get a boaster. It’s been 20 years since your last one and antibodies can wane over the years. Please get a new test done and a boaster could be the solution here if everything else remains negative. Thank you, Bright.

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Sorry, what do you mean ‘not accurate’. These are three different tests, so they seem like they are accurate (valid tests). Are they low because I have hep B and they are being used to fight it maybe?

I am referring to the surface antigen result that you are guessing might have become positive. False positive and negative do happen. Plus you do have some antibodies not high enough. So it doesn’t add up. Maybe a new surface antigen test with confirmation is needed plus a viral load test, should help clarify this problem. I hope this makes sense now. Sorry about the confusion

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Yah I’ll try and get new tests. Here are the ones I had though.

Dec 2023
HBsAg Qualitative (0.46, cutoff was 1.0 s/co so negative)
HBcAb IgG (0.1, cutoff was 1.0 s/co so negative)
HbsAb - not measured

February 2024
HBsAg Qualitative - Negative
HBcAb Qualitiative - Negative
HbsAb - 1.15 (< 10 is no immunity)

June 2024
HbsAg - can’t see
HbcAb - can’t see
HbsAb - 3.1m[iU]/ml (< 10 is no immunity)

So yah, at this point I don’t know. Seems like I have no immunity and may have tested positive for June (you only can’t see them if you’re positive for some weird reason here. someone should have called me, but nobody did).

I can empathize with you. It’s crazy having all these different results. Talk to your doctor and see what they think is going on here with this mixed results. Keep us posted. Bansah1

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Hi @Stargazer6138,

You’re right that a lot of the terminology is confusing. As I see it, these are separate issues:

  1. If you get the vaccination course, 95% of people will raise anti-HBs antibodies that completely protect against hepatitis B.
  2. If you’re unvaccinated, exposure to Hep B when you are an adult will lead to chronic infection 5% of the time and acute infection 95% of the time. The vaccine will improve this rate dramatically.

In many cases, this is mother to child transmission during birth and not during usual casual contact.

I agree with @Bansah1 and it is best to get the newest results directly to see them and get some clarity.

Thomas

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Thanks, appreciate the response.

As I said, I live in a country where positive STD results are for some reason hidden on the reports we get from the labs (I guess the idea being that the doctor should be the one to tell you). Unfortunately when I had my Hep B tests, it was done in the hospital, and the doctor never followed up, and I don’t have a family doctor. So these results are likely positive, since they don’t show on my report.

Another doctor is going to do a full set (HBsAg, anti-HBc, anti-HBs) shortly, and then we’ll see shortly.

I’m obviously concerned if I test positive that my health may be in jeopardy. But here if you test positive public health needs a list of previous sexual contacts to contact, as well as all your close family contacts you may have lived with. Which means I have to tell all of them right away since public health will tell them anyways (to get them tested and potentially vaccinated). I guess I’m really scared I may have accidentally given it to them. I know my dad has had high liver enzymes for a few years, same as my brother in law. I’m worried maybe they caught it from me and that’s why. They don’t usually test people here for Hep B unless you have some high risk exposure, as it’s such a low endemic country. For me though I’ve travelled to 45 countries so it’s possible I had exposure somewhere else.

Are there any documents are anything about household transmission and how likely it is some of my family may have got it. I last tested negative on a blood test six years ago, so it’s possible (if positive) I’ve had it for up to six years. I did live with them occasionally in their houses, so that’s my main concern now.

Thanks!

Dear @Stargazer6138,

Sorry to hear about this. It’ll be a bit more clear after you get confirmed results.

To your question, transmission between family members through casual contact (eating together, hugging, kissing, etc.) is incredibly low. Indeed, we have many people with hep B on the forum who have partners that have remained hep B negative for many years.

Hope this helps,
Thomas

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Thank you. I’ll know soon enough.

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Hi Thomas Tu and colleagues.
It is been while since I shared updates.
Today 23/09/2024 my test results showed as below.

  1. ALT and AST are Normal.
  2. AFP is down from 18 to 7.8
  3. HBV DNA (PCR) decreased from 20IU/ML to almost undetectable.
  4. Fibroscan showed Kpa 5 and doctor says it is very normal and says it’s between F0 and F1.
  5. Ultrasound showed normal.
  6. Hbeag is negative.
  7. Hbsag >1000
  8. GGT normal range.
    I AM NOT under any medication.
    The doctor was very positive? But could not take him very well.
    He says I need check up annually instead of 6 months.
    No coinfection!
    I feel tired and muscle craps still though in addition to confusion and lack of concentration plus speech problems.
    Please help interpret the results.

Help interpret this further please.

Dear @Wadani1,

Great to see you again and sorry that you are not feeling great.

Regarding your test results, they look great from a hep B perspective for the most part. There is little liver damage and your viral load is very low, suggesting that your immune response is controlling the Hep B very well.

There may be other causes of your physical issues that you and your doctor should consider investigating.

Thomas

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Thank you so much Thomas Tu. This explanation has been very useful.

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Please i need a response.
I tested positive for Hbsag positive. I was asked to go for HBV DNA detection Essay and it showed 3<10 IU/mL.
I was asked to get livolin forte.

Please I’m I on the right track

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Dear @tye,

Welcome to the forum. HBsAg positive suggests you are a carrier of hepatitis B, but your immune system appears to be controlling it well as you viral load is very very low (<10IU/mL). People with these results tend to be very stable and have low rates of disease progression.

The recommended course forward is to maintain monitoring (get blood tests every 6 months, and fibroscan) to see if your results change over time.

Thomas

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Thank you Doctor.
I should keep on with the drugs is what you are saying.

Dear @tye,

The most important part is maintaining monitoring.

We cannot make decisions about your medications on this forum (and indeed you shouldn’t take such advice from strangers on the internet). This is a decision to be made and conversation to be had with your health care provider.

Thomas

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Hello,

First of all, I would like to thank you for joining the community. I’ll say right away that a week ago I didn’t know that I would need support. I am writing on behalf of myself, but also on behalf of my husband.

We have been unsuccessfully trying to get offspring for several years. A month ago, we went to a clinic dealing with infertility treatment.

As you can guess, the first basic tests are all kinds of tests, including those for the presence of viruses. We have received the results and we have an appointment with a hepatologist this Saturday. However, this does not give me peace and here I send a request for interpretation of my husband’s results. The clinic said that we can return to the treatment of infertility with extracordic methods when the results are good.

I will add that about a year after my husband’s birth, his mother had hepatitis and has an anti-HBs gene present.

What should we know at the beginning of the struggle with this disease?

HBs - antygen HBs (WZW typu B) (V39) 5241,44 s/co obecny

HBc - p/c przeciw HBc total (WZW typu B) (V31)
6,14 s/co obecne

Albumina w surowicy (I09) 4,7 g/dL
Fosfataza alkaliczna (ALP) (L11) 90 U/L
Aminotransfereza asparaginianowa (AST) 28 U/L
Aminotransferaza alaninowa (ALT) (I17) 35 U/L
Gamma-glutamylotranspeptydaza (GGTP)
35 U/L
Bilirubina całkowita (I89) 0,76 mg/dL

Thanks in advanced for your support!

Anes

HBs - HBs antigen (Hepatitis B) (V39) 5241.44 s/co present

HBc - anti-HBc total (Hepatitis B) (V31) 6.14 s/co present

Serum albumin (I09) 4.7 g/dL
Alkaline phosphatase (ALP) (L11) 90 U/L
Aspartate aminotransferase (AST) 28 U/L
Alanine aminotransferase (ALT) (I17) 35 U/L
Gamma-glutamyl transpeptidase (GGTP) 35 U/L
Total bilirubin (I89) 0.76 mg/dL