Dear @Aneta_S,
Welcome to the forum and hope you get the support you need here. Some additional tests you might consider getting, include:
Hope this helps,
Thomas
Hi @ThomasTu
May you please help me interpret these results. Does it mean l currently have an infection and it has not shown up yet in the tests or its a past infection
Hepatitis B Surface Ag
Not Detected
N - Normal, applies only to non-numeric values.
07/10/2024 13:48
Hepatitis B Surface Ab
<10
IU/L
N - Normal, applies only to non-numeric values.
Hepatitis B Core Ab (Total)
EQUIVOCAL
Dear @availlant @ThomasTu
i did the test again for hbv dna, hbsag(iu/ml), hbcrag , hbeag,
1, hbv dna is now 154iu/ml
2, hbeag continue as seroconverted
3, hbcrag <3log10 iu/ml
4, hbsag is 174iu/ml
and my doctor told me not to start treatment and i never been on treatment also. but i have also follow up with private doctor and suggested me to be on vitamin E 400mg for 3 month to see.
Hi @Bae,
These results are consistent with not being exposed to Hep B and not being vaccinated. The general recommended action would be to get vaccinated so that you are protected from future exposure events.
Hi @lemlem,
Not treating is consistent with current treatment guidelines: your viral load is so low that any additional benefit from antiviral therapy (at least from a liver disease progression perspective) is not detectable in current clinical trials.
Hope this helps,
Thomas
Hi @ThomasTu
Thank you for the reply. I am now less stressed. I was worried about the Hepatitis core test (total) being equivocal , what are the chances that if l send a repeat sample l might get a positive. What causes such a test to come back equivocal?
Regards
thank you @ThomasTu well understand.
Hello,
Please let me understand the results.
HBsAg - positive
HBsAb - 0.0 (not immune)
Hepatitis B virus DNA (HBV) - not detected
Uhmm? How is it not detected if I’m diagnosed with it?
Additionally, Model End stage Liver Disease (MELD) score is 9.1
I have also elevated following enzymes:
ALP - 153 units (norm is 30-120)
ALT is ok, 31 units (norm 7-40)
GGT is ok, 20 units (norm is less than 64)
Also,
Elevated total bilirubin: 1.4 mg/dL (norm is 0.2-1.3)
Elevated indirect total bilirubin 0.96 mg/dL (norm 0.1-0.8)
Direct bilirubine is on the border of the norm: 0.44 mg/dL (norm is up to 0.45). And so is creatinine: 1.16 mg/dL (norm between 0.72-1.17)
I’ve been on TDF since April this year. Waiting for the info about viral load. This one doesn’t say.
So, I posted a while ago that I had some weird results, and I’ll just post them here. Despite being vaccinated 20 years ago, my HbsAb a few months ago was around 1 mIU/ml - the test said I basically wasn’t protected. They didn’t actually test HbsAg for some reason, even though they thought they did.
I knew I had another test to do, but I decided I would use the opportunity before hand to get a booster. So I got one shot of the engerix-b vaccine. At that point they wanted to test me, but I didn’t want to wait a whole month to test again as the doctor was waiting for it. So I waited 18 days, which seems like the minimum from a few studies they did.
On the retest, 18 days after my vaccination, the results were:
HbsAg - Non reactive
Hbs Core Ab (IgG + IgM) - Non reactive
HbsAb - 374 mIU/ml
So it looks like I don’t have hepatitis B I guess, which is good. My question is with regards to the antibodies, I know 10 mIU/ml is the threshold, but I suspect since this was only on day 18 that the antibodies will drop fast. Do people recommend I do another shot at the one month mark, or possibly one more at the six month mark (I completed a series in 2004)? I just want to make sure I’m protected for the last of my adult life at this point.
Thanks
Hello @Arb
Your results are only slightly over the limits.
This is normal.
Others will help answer your questions soon.
Hi @Arb,
@Caraline is right about some of your results being a little high. You do have hepatitis B, and the HBV DNA not detected means that the virus in your blood is low to be measured. Note that HBV DNA and Viral load tests can be used interchangeably. Which is what you want. The higher the viral load, the risk of liver damage increases. Many patients on treatment have undetectable HBV DNA. The liver panel, ALT looks normal but I don’t see AST. I am not sure what the other enzymes indicate. Since the other results are a fraction high, I will say keep your eye on it. TDF is working and keeping your viral load down which is good. Keep up with your treatment and monitoring. Best, Bansah1.
Hi @Stargazer6138,
Congratulations on your results. Your high antibody levels are a good sign that you’ll be protected for a long time yet. They are not likely to drop significantly in the short term. Regardless of your antibody levels, you have also now developed the memory B cells so that your body can respond extra quickly in case you are exposed in the future.
Hi @arb,
Your undetectable HBV DNA load is expected as you are on antiviral treatment. This is a good sign that the antivirals are working!
Hope this helps,
Thomas
Thanks Thomas. So with an antibody level like I have of 374, do you think I should do one more booster, or is that enough for the future?
Dear @Stargazer6138,
I am not sure, if you have started a booster series it’s usually recommended to complete that course. If you have completed the course, then there is no necessity to have additional boosters.
Thomas
Hi @Thomas
I had my results repeated and they are as follows
Hepatitis B Surface antigen [HBsAg] Not Detected
Hepatitis B Surface antibody [HBsAb] < 10 IU/L
Hepatitis B Core antibody (Total) [HBcT] DETECTED
So the doctor suspects that l may have been exposed to hep B in my childhood and have been asked to do the viral load test. My question is since HBsAg is negative is it possible l may have chronic hep B?
Hello again I had a question about recent blood work I’ve had done. My globulin and protein were high. I’m wondering if this could be a sign of reactivation? But I’m also not sure if it could be a Crohn’s flare for the reasoning if that could cause the elevation? Rest of blood work is normal. I have a follow up with GI and a CT scan this week. I’m just curious if there’s any chance I should expect to see a reactivation in hep b?
Hi @Bae,
If you are HBsAg-negative, then you do not have a current HBV infection.
It’s not common that you are previously exposed and you are both HBsAg and anti-HBs negative. It might be worth repeating to see if the anti-HBc test was a false positive. In any case, you could consider getting a booster so that your antibody levels are at protective levels.
Hi @Michaelmike223, the only way to check for reactivation is testing of HBV markers. Increase globulin and protein levels are not indicators of reactivation.
Thomas
Hello, I recently diagnosed whir hep b functional cure, please I need to know the risks of debellop hcc or transmiting the viruz during pregnancy. Please help my
Dear @Tathy,
Congratulations on your functional cure. If you do not have any existing cirrhosis, the risk of HCC is minimal after HBsAg loss.
If you are HBV DNA undetectable, then your risk of passing it on to baby is negligible (i.e., there has been no documented case ever of this happening). Birth dose vaccination for Hep B may also give you peace of mind.
Hope this helps,
Thomas
@ThomasTu
Thank you so much for your answer, it gives me peace of mind, I really thank you for your labor, te time you take to answer our questions, i wish you and your team success in all your investigations.
