The test for HBcAb has two variants: IgM (which is present during initial infection) and total (IgG + IgM). If you have been infected you will produce IgG HBcAb your whole life. As such you would always be positive for total HbcAb.
HBV < 10 IU/mL does not mean negative. It is not possible to prove the absence of HBV DNA with any test currently on the market. Most major HBV DNA test platforms will produce outputs of < 10IU/mL (which means the test cannot quantify the tiny amount of HBV DNA present) or target not detected (which means the test could not detect HBV DNA). This latter result is often not reported (left as < 10 IU/mL) out of caution and needs to be verified with the test lab but does not necessarily mean there is no HBV DNA present.
However, if you are total HBcAb negative and negative for HBsAg and HBsAb this suggests you have never been infected and should attempt vaccination.
Thank you for your response, especially for clarifying the <10iu/ml being used as a kind of “being on the safe side” of diagnostics. I was always confused when they said I was “negative” if there was some DNA detected. It’s an entirely bizarre situation to be honest as I can’t fathom any sort of clerical error that would cause me to be “misdiagnosed” over the course of two blood tests. However, I have decided to go ahead with vaccination and then worst comes to worse I have HBV but it’s under control and hopefully a definitive answer can be reached if I start producing antibodies after vaccination.
Hi @EH1999,
That is a good idea. There is not much to lose but you probably might gain more if you never had this virus. At least you will be protected. Once you complete your vaccine series, they can do a test to see whether you have immunity (HBsAb) and they can measure the antibody titers as well. That will provide another way of finding out whether you have HBV or not. If you do have it, you should not develop any antibodies. But if you do not have it, then you will develop antibodies from the vaccine which can then be tested and measured. HBV can be complicated at times, so try not to overwhelm yourself with all this. I know it is not that easy to ignore something like this. Hopefully, you can take care of the vaccinations soon. Best, Bansah1.
Hello again,
Sorry for the late reply, but i see that the other science experts took over with nice and extensive replies so hopefully it brought you some peace of mind.
I would just suggest to see if you could get back your results from when you initially arrived in Korea (i.e the ones you mentioned never had the paperwork in the end), as from your current results it seems indeed you might never had it, so it would be great to check these initial results and what led the diagnostic conclusion.
I agree you should attempt vaccination but keep monitoring your HBsAg level and antibodies to confirm further your negativity.
If you are/were indeed negative this whole time, i am very sorry for you, especially in term of mental health, worry, trauma and even stigma that the diagnostic might sadly have generated. I hope you found at least some help in this community.
Thank you for your response. Yeah, there’s no harm in doing the vaccinations, they’re relatively inexpensive in Korea so we’ll see what happens after the 6month mark.
No need to apologise! Everyone on here has a life outside of this forum so I understand entirely!
Yeah, I’m going to try and get my initial results from the hospital I went to when I first arrived. The way I see it there are three outcomes here: 1: I never had it which is great but annoying it took two and a half years to notice. 2: I do have it but it’s really well managed and just needs to be monitored. 3: I am some sort of mutant and did have it but now for some reason do not (I am of course joking)
Either way 6 months until I know for sure. The one thing I will take away from this at least is being told I did have HBV spurred on a whole host of lifestyle changes that definitely needed to happen and I’m living much healthier because of it.
Hi experts, I was wondering if you could help interpret my lifetime HBV test results:
According to my parents, shortly after I was born, I was very sick, and when they took me to the hospital, doctors told them I had hep B. I obtained my test results and they were as follows:
I think the doctor also wrote “GPT 260”, which I believe might mean ALT level?
I was tested again at 7 months old and 5 years old, negative for all 5 of these markers each time. All of these childhood tests were done in a developing country with questionable medical processes. At age 21 I took a total HBcAb test (this time in a developed country), which was negative.
Based on my understanding, it’s not possible for HBeAg to be positive and HBsAg to be negative. Given the 3 subsequent negative tests, is the most likely scenario that the first set of tests were unreliable, and that I actually had something like mono or another viral infection as a newborn?
Hi @throwawayhb321,
Welcome to the community and thanks for sharing your story and results. If HBeAg was positive at 3 months old, but was negative on subsequent tests then it is possible the first positive test was false. And you are correct to point out that without someone having the virus in the first place they cant replicate something they don’t have. This makes me strongly believe the false positive incident. With the GPT being 260, it is possible to have had some liver issue that was not hepatitis B related. Some babies develop jaundice at birth and with light therapy or exposure to sunshine they get over it.
Have you been vaccinated? If not, I will recommend you do so as soon as possible. I hope this is helpful.Bansah1
Yes, I’d agree with @Bansah1 that some of these tests may have been false positives and that vaccination (if you haven’t already been vaccinated and seen your anti-HBs Ab at protective levels) should be strongly considered.
The four new recommended options for meeting treatment eligibility will substantially expand treatment access to most individuals testing positive for HBsAg. There may also be individual circumstances in which, although individuals may not meet any of the four options for treatment eligibility, there are specific individual concerns regarding infectivity, transmission, associated stigma, the risk of oncogenicity and progressive liver fibrosis and a strong individual motivation
to consider treatment, despite the lack of direct evidence. In such cases, a patient-centred approach with discussion between individuals and their health-care provider will be key in helping them make informed decisions about whether to begin treatment or not. This should consider the uncertainties resulting from lack of direct evidence for treatment benefit and low risk of transmission for those with HBV DNA <2000 IU/mL, overall lower benefit-to-risk ratio, the financial implications associated with long-term treatment and importance of sustained treatment adherence.
Hi,
I am 36 years old i was accidentaly diagnosis with chronic hep b 5 months ago… my hbv dna was 890iu/ml
And my hbsag was 2800 , hbeag was negative and anti hbeab was positive, fibroscan was 5.8kpa and lft was normal ultra sound was also normal no damage of liver… dr started my treatment with TAF 25 mg once daily… its been 5 months my hbv dna is not detected now lft are normal but my hbsag is fluctuating after i have started the treatment , i have done my hbsag test twice once it was 2000 in april and in june24 it was 2600…
Am i at the risk of liver disease… or its inactive hbv… will it damage my liver???
As mentioned in the other thread, the risk of disease progression from Hep B is low when you’re on antiviral therapy and particularly if you don’t have existing liver disease the risk of cancer is also low.
These testes were done recently on my follow-up check up after 9 months of taking Tenofovir.
I have been asked by my Hepatologist to stopped Tenofovir treatment base on the result. What’s your advice please?
Hello dear friends, I am new to this group and I was diagnosed by accident last year on 8-2023 and I was positive in chronic form.
I don’t know how many years I have had this disease. So my questions are:
Can I take hepatitis B medication based on the hbsag marker?
How can I know how many years I have had this disease?
what is the factor that changed the amount of hbs ag in a significant way ?
