Is it possible to lose surface antigen after only 12 weeks of peg-IFN? I’m in the AB-729 study, did the trial/AB medication for 6 months and now was randomized to the lowest arm, which is maintaining my TAF (been on for many years) and IFN for only 12 weeks. Every study out there has IFN for standard 48 weeks when reading online, so was really bummed about the 12 weeks. Ive only had 2 doses (180mg IFN) but so far have not had any bad side effects.
Lastly, since I’m doing well so far is there any changes study doctor can ask trial if I can have more time on IFN (2 arms in this study have IFN for 24 weeks). I wouldn’t think so, just bummed I can’t get more time to try and kick the HbsAg for good! I’ve had hbsag my whole life, almost 50 y/o and genotype A. Thanks!
The doctor recommended to me is from a hospital in Shenzhen, China. Before receiving PegIN, I had already understood its advantages and disadvantages, mainly muscle pain in the body and economic burden, which I can accept. My goal is to reduce my HBsAg through this drug, so I quickly accepted this treatment plan. Now I have used PegIN 6 times and my HBsAg has decreased by 40% after using it 4 times, Now HBsAg (2200 IU/ml).
After 40 jabs of peginterferon, I just had to stop. The weakness, loss of appetite, mental health became unbearable.
Now, I am having to deal with new challenges, including general feeling of sadness, mood issues etc and also weakness. Not much help comes from health care around me as they have limited understanding and management of post pegasys treatment related issues.
I have been off peginterferon for 2 months but my side effects impacts my daily routine, eg, mood swings, anxiety, loss of appetite, hoarse voice etc.
My Fibroscan is OK plus blood tests as at March 2023.