I’ve been here for a while and enjoying the topics, discussions and experiences shared in this community. I am grateful for finding so much information about HBV as I am a CHBV female who wants to know more about treatment, invention and development of a new cure for HBV.
In spring, 2020 I was diagnosed second time with CHBV and took it in serious, because the first time being diagnosed (10 years before the second diagnosis) I was told not worry about it and that I will have a long and normal life and completely didn’t care about HBV. I have to mention that my mother died 9 years ago because of the complications of HBV+HDV and HCV.
My twin sister had HBV too (diagnosed with me in 2010)but in 2020, her HBsAg was negative and HBsAb positive (>1000).
Since 2020, I have been participating in several trials and a year ago I’ve started taking TDF. My DNA has been undetectable 3 months after starting TDF(the time when I repeated DNA test).
My HBsAg levels were:
September 2020: 4634,00 (different laboratory)
05 May 2021: 2173,47 IU/ml (my preferred lab)
May 2021: 1401,00 (different lab)
Anti-HBs 2 IU/L
June 2021: 980,00 IU/ml (different lab)
10 September 2021: 9116,00 IU/ml (different laboratory, I was shocked seeing this result, then I decided to repeat it at a laboratory I usually do it)
28 September 2021: 2050,00 IU/ml (my preferred laboratory before starting taking TDF)
April 2022: 1650,33 IU/ml (my preferred laboratory after 6 months of TDF)
October 2022: 67,9 IU/ml (my preferred lab) after one year of TDF and plus about 22 weeks on AB-729.
My question is, if HBsAg level has dropped so much since last time (6 months apart) might rebound after being off medications (TDF, AB-729 and Pegasys)?
Or, HBsAg is not able to rebound as HBV DNA does?
I am participating in AB-729 trial and want to know what might happen/to expect after stopping taking the medications.
What are the expert opinions?