When can i stop taking truvada

What do my lab results mean?
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Ten months ago, I tested positive for Hepatitis B during a routine clinic check-up. My baseline labs showed HBV DNA of 802 million IU/mL, AST = 38 U/L, ALT = 120 U/L, HBeAg positive, and Anti-HB positive.

I was started on Truvada, which I have been taking to date. In March, I repeated my LFTs ā€” AST was 75.1 U/L and ALT 298.7 U/L, while HBV DNA had dropped to 2,118 IU/mL.

In the June follow-up, both AST and ALT were normal, HBV DNA was undetectable, and Anti-HB remained positive (2.8 titre).

In the last two months, my HBsAg has become negative, but Iā€™m yet to do the remaining tests scheduled for December.

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Hi @Takawa,
You can stop when your symptoms have all passed, have seroconverted surface antigen from positive to negative with normal ALT, AST, and undetectable HBV DNA, along with normal liver imaging. All these must be considered, and the test results must be consistent through a couple of tests. One test alone is not enough to recommend ending treatment. Keep us posted. Best, Bansah1

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Hi @takawa,

Generally 6 months should pass between two HBsAg-negative results to confirm persistent clearance of infection before antivirals are ended.

Thomas

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