Therapeutic vaccination for Hepatitis B

General Discussion Lab results
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Hello dear friends, I found a study on the net Therapeutic vaccination for treatment of chronic hepatitis B - PubMed . Therapeutic vaccines in treating chronic hepatitis B: the end of the beginning or the beginning of the end? - PubMed One year ago I had the SARS-CoV-2 infection and they gave me monoclonal antibodies for SARS-CoV-2, two months after this treatment my HBsA increased from 0 to <3.1 mUl / mL. The doctor suggested that I get the vaccine for HEPATITIS B immunization and maybe I can stop those AcHBs from 3 to millions of antibodies and maybe Aghbs becomes negative. Vaccin antihepatic B - Wikipedia The infectious disease doctor said that there are studies in which Aghbs was eliminated after vaccination with the hepatitis B vaccine, especially since I have antibodies against Aghbs, they are quantitatively < 3.1 mUl / mL and if I take the therapeutic vaccine against hepatitis B the anti-HBS antibodies may increase from < 3.1 mUl/mL to millions and in this way maybe I am lucky and Aghbs is eliminated. What do you think ? what are the risks in the future? The doctor refers to this study What do you advise . Therapeutic vaccination for treatment of chronic hepatitis B - PubMed Therapeutic vaccines in treating chronic hepatitis B: the end of the beginning or the beginning of the end? - PubMed
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The doctor said that this vaccine Vaccin antihepatic B - Wikipedia will it help me to increase the amount of AcHBs < 3.1 and Aghbs to become negative, what do you think? what are the risks if Aghbs does not become negative but I will also have AcHBs, will it lead to liver inflammation, can the degree of fibrosis increase over time?

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Hello @MARIAN
I have no knowledge about this but seems very interesting.
Someone with more knowledge with answer soon.

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I mention the fact that I am not on hepatitis B antiviral treatment, there was no such thing because the highest viremia was 64 Ul/mL and the lowest < 10 Ul/mL , in these 2 years since I found out that I have this virus .

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Dear @MARIAN,

Thanks for bringing up a very interesting topic.

The paper you refer to is out of date as a great deal of good work has been done with therapeutic vaccination since then. Multiple major drug companies and one large academic consortium are starting clinical trials for therapeutic vaccination using the latest technologies. I am personally excited to see the results, but with caution in my thinking. Therapeutic vaccination has been explored for as long as I’ve been studying HBV (~30 years), and in all that time, the only impressive results are the ones that are coming out now (for example TherVacB; https://www.thervacb.eu/), and those are still pre-clincial data.

As to getting re-vaccinated with the standard HBV vaccines: That will not hurt anything, but long experience with the vaccine in HBV+ people has not led to good results. There is always a chance that you are on the cusp of naturally seroconverting to anti-HBs positive state (ie, a natural “functional cure”–this happens rarely but it does happen) and re-vaccination might push the virus over the edge. However, there is no substantial body of clinical or lab-based data saying that would work.

I wish you the best.

John.

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