To monitor the health of my liver, my doctor has prescribed annual MRCP (Magnetic Resonance Cholangiopancreatography) examinations with contrast, along with regular ultrasounds, for many years. Fortunately, all of my results have consistently shown normal findings, except for the presence of several cysts. However, recently I came across an article discussing the potential risk of Gadolinium retention in the brain and bones, which has caused me some concern.
I would greatly appreciate the insights and expertise of the professionals here. Should I be worried about the potential risks associated with Gadolinium retention? Is it necessary to undergo yearly MRCP examinations with contrast, or could it be considered excessive? Would two ultrasounds per year be sufficient for monitoring purposes? Additionally, I am curious to know if MRCP without the use of contrast is a viable alternative.
Thank you in advance for your valuable input and expertise in addressing my concerns.
Thanks for your question. I am not a GP or a radiologist, so am out of my expertise. But the statements from sources I consider trustworthy (including NSW health - https://www.health.nsw.gov.au/sabs/Documents/2017-si-002.pdf; Australian/New Zealand college of radiologists - https://www.ranzcr.com/whats-on/news-media/171-ranzcr-statement-on-gadolinium-retention; and US FDA - FDA Drug Safety Podcast: FDA warns that gadolinium-based contrast agents (GBCAs) are retained in the body; requires new class warnings | FDA) seem to suggest that there are no known adverse effects based on the small amount of retention of the contrast agents. Also there are appear to be formulations that accumulate less macrocyclic vs linear contrast agents.
Your doctor has likely come to the decision that the adverse risks of not screening outweigh the possible adverse risks of not screening and presumably has discussed these with you. If you have concerns, you should raise the concerns with them.
Thank you Thomas for your input. I appreciate it.
There is a fine line between over-testing and under-testing for a chronical disease like HepB. I’ll definitely discuss my concerns with my specialist at my next appointment.
Thanks @WeStrong, wish you all the best and please keep the community updated on your progress.