SGA due to TDF exposure in utero

Hi everyone, I’m currently 32 weeks pregnant and started taking TDF at 20 weeks due to a high viral load. Within just four weeks of starting the medication, my baby’s growth dropped significantly—from the 50th percentile to the 15th, and now at 32 weeks, it’s down to the 13th percentile.

Since then, I’ve increased my calorie intake and made a conscious effort to include more nutrient-dense foods in my diet to try and offset any impact the medication may be having on the baby’s growth. I’m really anxious and hoping my baby doesn’t become growth restricted.

Has anyone else gone through something similar while taking TDF during pregnancy? I’d be so grateful to hear your experiences—was your baby born with a normal weight or did they have low birth weight?

The one reassuring part is that my viral load is now close to undetectable, but I’m still really worried and would deeply appreciate any insights from those who’ve been through this.

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Hi @Kisscurl,

Thanks for sharing your story and sorry to hear about your situation. It must be really stressful for you and your family.

I’ll let mothers talk to you about their own experience, but just wanted to provide some moderate size studies (400-1000 people) and meta-analyses that show that TDF is not associated with any detectable clinically-significant differences in fetal growth or development:

Happy to have any additional comments from @HealthExperts or @ScienceExperts on this.

Cheers,
Thomas

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Agree
There is extensive data on safety and recommended by most experts
FYI We published a review article
https://onlinelibrary.wiley.com/doi/full/10.1111/liv.15249
best
Carla

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