Many therapies can claim to reduce the Hepatitis B virus levels. Is it a cure? For every chronic HBVers? What is it?
From what I can tell, the sample size was very small. Interestingly, the clinical trial doesn’t seem to have any restrictions on baseline HBsAg like some of the other trials do, but we don’t know the baseline HBsAg levels of the patients who responded. I guess we will have to wait until the study is complete, because then we should have more detailed data available.
There is some data in the presented poster: https://www.viriontx.com/wp-content/uploads/Currie-CROI-2026-587.pdf
It shows that the responders who got to undetectable started off with a HBsAg level of less than 100, but all the patients they are showing reduce their HBsAg levels by >100-fold regardless of baseline levels.
Thomas
Thank you @ThomasTu! Okay, so it looks like there were restrictions based on HBsAg, according to the poster that Thomas attached, even though it doesn’t say so on clinicaltrials.gov.
If I’m being honest, I don’t think that the results from VRON-0200 alone look all that impressive, as only 4/27 patients had at least a 1 log decline. The people in the combination cohort 3 appeared to have better results, but again, that was only 8 people.