Key questions in the HBV field

Expert Chat
1

Hi all,

Please use this thread to discuss what you see are the most pressing scientific questions in the HBV field.

TT

2

When to stop long-term NUC Therapy?
Expanding Treatment Criteria?
Personalized Medicine - Tailoring treatment
Increasing linkage and access to care, reducing disparities

Long-term how / when can we achieve functional cure with current pipeline

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Thanks @cscoffin,

Agree with all of these. From my perspective (biased because of my own research):

  • What does integrated HBV DNA do?
  • How does cccDNA persist in the liver?
  • Can we develop a model that mimics the pathogenesis associated with HBV? Can we address it?
  • What is the reason some HBV genotypes are more responsive to therapy (or treatment cessation) than others?
  • How did Hep B evolve and where does it originate from?

From reading the forums, I think some important questions from the community include:

  • How can we best address HBV-associated stigma and mental health aspects?
  • How do we reduce the amount of side-effects associated with Hep B?
  • When are people really non-infectious? Does undetected HBV DNA = untransmissible?
  • Are there optimal foods or lifestyle choices that can reduce liver disease progression?
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