I am writing to seek clarification regarding my recent HBV test results. Here are the details:
• HBsAg: Positive
• HBeAg: Negative
• HBc core IgM: Negative
• Liver Function Tests: Normal
• Fibrosis Level: 7.7 kPa
• Weight: 62 kg
• Height: 5.7 inches
• Age: 25
Given that my liver function tests are normal and I have a negative HBeAg
Hi @ ASR_Property
From your limited information about your HBV profiles , I think that you are in HBeAg -ve chronic HBV infection or inactive carrier stage with normal BMI but your fibrosis level = 7.7 k Pa that mean you have significant fibrosis in your liver. However, liver stiffness measurements may have some limitations and there are some factors that the results of your fibrosis levels may be overestimated eg you are not NPO before procedure, your hydration status, IQR range or standard of machine if you aren’t high risk groups eg alcohol drinker, smoker. The other way you may using other non invasive tests like APRI, FIB-4 and compare with your fibrosis results to make sure that it isn’t real significant fibrosis. You should consult with your doctor about further available HBV investigations like HBV DNA level.
chul_chan
Chulapong Chanta MD. Pediatric.
Hbv dna viral load <10 what that means my immune system can eliminate it
Yes , it means that your immune system can control transcriptional activity of cccDNA so it can’t produce HBV DNA into your bloodstream as that we call like partial cure .
chul_chan
I don’t have bad habbit smoke alcohol etc from my childhood
Is there chance HBsAg become negative in future
Based on my report
In general, the rate of spontaneous HBsAg seroclearance is about 1% per year and it depends on some factors such as adult onset or perinatal acquired HBV infection , HBV genotype, advanced aging, HBV DNA level depending on evidence based from research studies. Adult onset with chronic HBV infection may have chance to clear HBsAg than perinatally acquired because of duration of infection and host- viral immune response.In your case report , you have likely chance to become HBsAg - ve in the future due to your inactive carrier /immune control status with low HBV DNA level and your body immune system is active according to your healthy life style and I hope that if you maintain this habit and regularly follow up for HBV profiles annually, you may have spontaneous seroclearance of HBsAg eventually . Cheers.
chul_chan
Chulapong Chanta MD. Pediatric
Hi @ASR_Property,
I agree with @chul_chan. In addition, maybe an ultrasound could help with further liver evaluation here as well. HBV DNA or viral load is different from HBsAb. Your immune system can clear HBV and develop immunity. The viral load can be lowered with management, but not eliminated completely. Surface antigen loss is possible depending on how low your quantitative value/number is, how your immune system is fighting this virus, plus treatment. It is worth adding that the number of people who achieve this through treatment is very low, about 5%. I hope this, in addition to what @chul_chan has shared, is helpful. Best, Bansah1
I believe in you are in the Immune Control Phase of your chronic HBV infection. This phase may last a lifetime (until we find a cure or your immune system cures yourself), but potentially can change to the Immune Escape Phase. In the Immune Escape phase, you will need treatment. I suggest you measure your serum HBsAg in your next blood test. This will give you a better idea whether you are truly inactive and close to a functional cure. If your serum HBsAg is very low, you can discuss with your doctor regarding the use of Interferon treatment to achieve a functional cure.