Hepatitis B positive treatment viral

That means i could safely continue taking my drugs??

And I suspect that, I see it while researching that 150mg of lamivudine Is much for hapatitis b instead 100 is better ?. Coz I am taking 150 and am dying of side effects already??
How true is this?

Is there anyone who have taken lamivudine here before,I am even experiencing a testicular pain

Out of fear and lack of knowledge about hepB, I and my sister started taking Lamivudine. We will start and stop and start again, until I later found this group. I was educated about the possible resistance that may come from taking Lamivudine, I later switched to tenofovir. This is one mistake that I made because I didn’t know if I would benefit from treatment or not. But fortunately for my sister, when I told her about the possible resistance that may occur, she went back to the hospital after she has stopped taking Lamivudine and tested for HBsAg and the result was ‘non-reactive’, she did that in several hospitals and the results were the same, she bought the test kit and did a home test, it came out Non-reactive. I don’t know why her status changed and I can’t attribute it to any thing yet since I’m not knowlegeable enough. Our parents are both free from HepB but three of us are reactive, when I was diagnosed with hepB, I have never had any sexual encounter, never used drugs nor had blood transfusion and tatoo. Lately I found out that our cousins that lived with us are both hepB positive and I was wondering if we got infected through them and through what means? I’m very much confused about the transmission routes. Maybe @ThomasTu and @availlant will educate me more.

What about you? Are you still taking your medication? Tenofovir I mean and how many milligrams?

Dear @Smart55,

HBV is most easily transmitted by sharing needles for IV injection or sexual intercourse. It can also be transmitted from mother to child during birth. HBV transmission from casual physical contact is unlikely but the virus is very stable outside the body for at least 7 days so contact between an open cut and an object or surface that has HBV can lead to infection.

You say that your parents are HBV free but I wonder if this has been determined with a HBcAg total IgG or IgG test for your mother? It is possible that she is HBsAg negative and HBV DNA negative but has resolved a pre-existing chronic infection. I would investigate this possibility (maternal transfer) first before considering less likely possibilities.

In your sister’s case, it appears that she has achieved functional cure as she is HBsAg non-reactive. We still don’t understand all of the factors which play a role in the shift from acute infection to resolution (functional cure) or chronic HBV. However we know chronic HBV is most often resulting from maternal transfer or getting infected when very young, very old or when immunocompromised.

@availlant

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@availlant Thank you so much for always availing us your time and for the responses. The only test my parents took was for the surface antigent, I’m not sure they ever had the profile test and other tests. Thank you once more for this detailed explanation.

@adeleke_afeez Yes I’m still taking the Tenofovir 300mg. I don’t have access to Tenofovir Alefedamide which is more safe against renal impairment, I would have switched. But before I started taking Lamivudine, I had liver function test and EUCr, the results were good.

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Does hepatitis B affect the kidney too ,I thought it’s liver only?!

Does both lamivudine and tenofovir can cause Rena impairment?

I thought tenofovir had less side effects??

I didn’t do the test but I only had my profile done but I was mostly placed on the drugs Bec I didn’t have any surface antigen antibodies against it , it was negative and I am sick :nauseated_face:… that’s probably why …

But I will further on t try to talk to an experience Doctor but no response yet …I am trying to reach one of the doctor offer by the foundation around here to know everything
I am sure talking to a nominee doctor would be more safe and definitely I am switching to tenofovir or I could talk about using 100 mg of lamivudine instead of 150mg am using since I am experiencing a side effects

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I would appreciate further clarification on the side effects of tenofovir alafenamide and tenofovir 300mg. I was among the people who are enrolled on the AFRICAN LIVER PATIENTS ASSOCIATION medical assistant, so I just collected the medicine yesterday. They do not tell us about any side effects, that’s why I got surprised when I saw this reply. Can you please elaborate your opinion on that?

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I am talking about lamivudine, I wanted to switch to tenofovir too because it has a less or no side effects know…

I wish I could be enrolled in that too and got the drugs for free :unamused:
It’s costly

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@adeleke_afeez Definitely, talking to a specialist is the ideal thing to do. Well, the mistake I made was I didn’t see a doctor before I started treatment, I started treatment out of fear after several attempts to book an appointment with a specialist were not successful. I relied on information online and that was how I discovered this group. I did the EUCr to make sure my kidneys are okay for daily dose of 300mg of active ingredient in Tenofovir, which from what I gathered is necessary before taking TDF. However, TAF is more tolerable as it is 25mg/ tablet. Before you switch medications,I will advise you consult your doctor, else @availlant and @ThomasTu among others have been very helpful here.

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@Zigau There’s a leaflet inside the container, you will see all the possible side effects on it. People react to medicines differently. In my case, when I started taking Lamivudine, I didn’t experience any side effect, but when I switched to TDF, I had mild side effects for a few days and afterwards, everything became normal.

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Dear @ Smart55

This is a general note for the community to address confusion and safety concerns between TDF and TAF. This is important because TDF is cheaper because its patent protection has expired and there are many generic versions on the market. The difference in potential adverse events between TDF and TAF is not a function of the dose but instead where the active component (tenofovir aka TFV) resides with treatment.

Both TDF and TAF are prodrugs of TFV. This means that they have chemical modifications which alter how they get distributed in the body. In the case of TDF, TFV is modified with disoproxil fumarate. In the case of TAF, TFV is modified with alafenamide.

The “warhead” of these molecules (tenofovir) provided all of the antiviral activity but has poor oral bioavailabilty. TDF was the first approved version of TFV (which has good oral bioavailability). TAF is also orally bioavailable but gets preferentially concentrated in the liver. So with TAF, similar liver concentrations of TFV can be achieved with a lower dose of drug.

Both these drugs have comparable activity against HBV infection. However, in a small proportion of patients, prolonged exposure of TDF can lead to kidney dysfunction and bone demineralization. Switching to TAF in these patients can reverse these side effects without compromising antiviral therapy.

However, many patients have taken TDF for many years and show no side effects. In many cases, these side effects take many years to develop and are not severe enough to really need to switch medications. Some patients have tolerability issues with TAF and some patients have tolerability issues with TDF.

Unless you have underlying kidney disease, there is no reason to feel you have to take TAF (it will be more expensive as there are no generic versions yet on the market).

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@availlant Thank you once more for this vital information, it is quite educative. @adeleke_afeez Please refer to the comment by @availlant

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I wanted to know about my sexual Life :nauseated_face::dna:

Am no womanizer and been having sex for a while untill with a single girl

I doubt :face_with_monocle: I contract it from here but In a year and half we haven’t had a flesh sex , we used condoms all the time … I want to know if it’s good to continue like the until am sure of my blood … She feel good and she didn’t feel sick :nauseated_face:
I don’t know how I might have contracted it

I want to know more

I wanted to know too if I have my LFT done :white_check_mark:
Will it show my viral load percentage r not ?

Hi @adeleke_afeez,

The majority of chronic Hepatitis B cases are due to exposure when you’re a newborn (e.g., mother to child transmission) or during childhood (e.g., through scratches or medical procedures). Hep B can be asymptomatic for long periods of time (many decades). It may not be possible to know when and how you got it.

LFTs will not show you your viral load, this is a separate test (PCR)

Thomas

Thanks you for your suggestions

Apparently I talk to one of the specialist recommended by hepatitis B foundation for my country and he told me to go for LFT,full blood count and abdominal scan

I think Base on no indicator for my platelets counts and my LFT

He told me to stop taking the medication and not yet in a situation for me to start treatment .

He said my symptoms is based on another illness which I suppose it’s typhoid I treated before I tested for Hepatitis B…I will go for the full treatment again…

And he told me to wait it out after 6 month and run another test again as to know if I still have it then … and after Some tests too ,I can then go for medication but now he said I am not qualified to be treated as it’s the same as using wrong medication and since my scan and LFT is ok I can withdraw from the drugs

I wanna thanks everyone one here for guidance givens and the Hepatitis B foundation for letting me talk to you people and a specialist that help me out…
If I have known about this before,I won’t have been treated wrongly bcse doctor here aren’t a specialist of this disease…
I hope I find health again and be free until I go for another test .

Thanks you all :heart::heart::heart::heart::heart:

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Oh good news bro. Which treament you were on?