Hi everyone! I recently signed up for the B-United study to research a potential cure for hepatitis B. It is a sequential study with daplusiran/tomligisiran, followed by bepirovirsen. I know that there have been multiple other trials with bepirovirsen only, so I feel hopeful that this can help. It looks like it might still be recruiting. Curious if anyone else here is participating in this one?
https://www.bunitedstudy.com/
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Update:
I just got my 3rd injection last week. I’m currently 2 months in since starting treatment with the study drug. Feeling slightly frustrated/discouraged because my surface antigen levels are more or less the same as when I started. That being said, this first phase of the study with daplusiran/tomligisiran might be a placebo, and neither I, nor the study doctor knows which treatment arm I’m assigned to. The good news is that even if I’m getting placebo now, the second phase of the study includes treatment with bepirovirsen, and there is no placebo for that phase.
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Hi @et5656,
Your frustration is understandable, but these things take some time to see their effect, hence the multiple injections. Could it be that you are receiving a placebo? Which can be difficult to tell because no one knows who is getting what. A unique feature of a randomized clinical trial. Hopefully, things begin to look promising down the road for you. Keep us posted. Bansah1
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I pray for your recovery. Thanks for keeping us posted.
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I just got my last injection of DAP/TOM, and I start treatment with Bepirovirsen next month. My HBsAg has started to go down, but not as much as I hoped. It usually takes a few weeks for me to get the blood test results, so the latest ones I have are based on the results after 4 injections. My HBsAg has gone down by 38% so far. I started at 458, and now I’m down to 288. I think I expected that it would have gone down by at least 60% at this point in time, but it’s not over yet.
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How did you all learn about these trials? Is there something to subscribe to?
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Hi @bornwithhepb,
You can check on clinicaltrials.gov and visit the hepatitis B Foundation’s website to sign up for their monthly newsletter, which sometimes shares information. Please speak to your doctor, as they may be aware of additional options. For example, my doctor conducts some of this research, so he will bring it up during a visit, or I will ask him about the latest happenings in the clinical trials world. I hope this is helpful. Bansah1
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Just to expand a bit more on @Bansah1’s comment, the appropriate HBF site is here: Clinical Trials for Hepatitis B » Hepatitis B Foundation
TT
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