EXPLAINER: Lab results and their interpretation

Please I need an interpreter for my result I have been vaccinated for hapitte B since 2021 to 2022 including 3 does I have done 2 medical test for fitness and I was fit
This year I went for another blood test and doctor said I have a reactive hapitte B of the following hbsag reactive, hbsab reactive, hbeag non reactive, hbeab reactive and hbcab reactive and Noone could explain to me and I’m dying thinking on what to do am confused just don’t know what to do now please any help

Dear @Anthony_Oscar_Kamara,

Welcome to the forum and thank you for sharing your story. I understand that it is very stressful at the moment.

Being HBsAg-positive means you have a current infection of hepatitis B. You may have had this before your vaccination, which would have had no effect if you already had it. Hepatitis B is a manageable condition that many other people on this forum (including myself) have and live with.

It is important that you keep monitoring to: 1) confirm these blood results accurately reflect your condition; 2) to understand your liver health; and 3) to determine if you would benefit from treatment or if it is OK to just keep monitoring your condition for now.

Hope this helps,
Thomas

Dr, am trying to do another test again but the country am currently is diffult to live with hapitte coz all test of it must knows by the government
Regarding my vaccination I did it 3yrs back even before my vaccination I want for a medical test which showed I am fit.
So that mean I was negative of it
Earlier this year I went home and doctor said I’m reactive of it. But like you said I will fight to redo the test again.

Hi @Anthony_Oscar_Kamara, I’m not sure about what the initial tests were and these do not necessarily test for existing infection.

Thomas

HI.
Should I post here before asking for results interpretation ?

I’m not sure how I got it since I’m in a monogamous relationship and I don’t see anyone else. I use cocaine from time to time and my doctor said I could have been infected while sharing straws.

First tested on 13/03 after feeling a bit sick, I got positive on HBsAG and negative on the rest.

First test results

HBs Antigen Test: Positive
HBsAg Index 6.84 S/CO < 1.00
Anti-HBs Antibodies <2 mIU/mL Immunity > 10
Total Anti-HBc Antibodies Test: Negative
Anti-HBc Antibody Index 0.06 < 1.00

HBV DNA DETECTION AND QUANTIFICATION (TMA)
Reagent Kit: Aptima HBV Quant Assay - Hologic
< 10 IU/mL
No HBV DNA detection. Quantification range: 10 - 1,000,000,000 IU/mL (1 - 9 log)

HEPATITIS B SEROLOGY (Enzyme Immunoassay) #
Sample taken: 03/13/2025 Serum
Anti-HBc IgM antibody (Cobas Roche) Negative
<0.9 Threshold: 1.1
No serological evidence supporting acute hepatitis B infection.
Result to be interpreted based on the entire clinical and biological context.

I took a second test one month later on the 26/04 and got a negative result on HbsAg but haven’t developed antibodies (negative all over). Should I worry or am I in the clear ?

Second tests results

SERODIAGNOSIS OF VIRAL HEPATITIS B
(1) (Chemiluminescence)
03/11/25
HBs antigen test Negative
HBsAg index 0.44 S/CO < 1.00

Anti-HBs antibodies <2 mIU/mL immunity > 10 <2
03/11/25
Total anti-HBc antibody test Negative Negative
Anti-HBc antibody index 0.05 < 1.00 0.06
Interpretation: Absence of serological markers suggesting contact with the hepatitis B virus.
In case of suspected recent infection or a risk situation, these markers should be checked in 3 months. Vaccination may be offered according to the vaccination schedule.
Results should be compared with the clinical context. (HAS January 2017)

HEPATITIS B SEROLOGY (Enzyme Immunoassay) #
Sample: 04/25/2025 Serum 11:22 AM
Anti-HBc IgM Ab (Cobas Roche) Negative
<0.9 Threshold: 1.1
No serological evidence in favor of acute hepatitis B virus infection.
Result to be interpreted based on the entire clinical and biological context.

HBV DNA DETECTION AND QUANTIFICATION (TMA)
Reagent kit: Aptima HBV Quant Assay - Hologic
< 10 IU/ml
No HBV DNA detection.
Quantification range: 10 - 1,000,000,000 IU/ml (1 - 9 log)

Just wanted to know if I’m all good or not cleared yet from the acute infection.
Thank you in advance !

Hi @JeanGenie,
Welcome to the community. If I understand correctly, these two tests happened a month apart, right? If that is the case, I am not sure the results were accurate. Why? I’m unsure if you were infected and cleared it within a month. Plus, you still do not have any antibodies. This makes me believe that one of these results is false. I will recommend taking the test in 2 months with confirmation. If you test negative for HBV and still have no antibodies, the vaccination is the best way forward. Please be careful so you do not get exposed to other infections when sharing with others. Best, Bansah1

I suspect I caught it in January. I had a big party and I didnt pay that much attention to my own comsuption.
I will definitely retake a test in two months. Thank you for your reply!

Sure, lets see what the results are in two months. Sharing with others is a possible mode of HBV transmission and vaccination is the best protection against HBV. If your surface antigen and antibodies remains negative with no viral DNA, then you will need to get vaccinated as soon as possible. Take care and keep us posted. Thanks, Bansah1