EXPLAINER: Lab results and their interpretation

Thanks for the response I’m sorry you’ve been battling this for so long. Yea I was more curious if fatty liver could be related to having or have had the virus. But I’ve actually lost 40 pounds and have been eating a better diet since that test so I’m seeing my doctor after an ultrasound next week so I will get some answers. Figured I’d post here to hopefully get some idea of what I’m walking into. So your fatty liver is unrelated to the hep? Again thanks for the response! Wishing you all the best!

Dear @Michaelmike223,

There are 2 possibilities here. First, the test could have been a false positive as your physician originally speculated. All tests, including medical ones, have an error rate. Those rates are usually very low and come into play only when trying to detect very low levels of the target. However, this is inconsistent with the persistent HBV core antibody positivity.

Therefore, I think you had a very short term HBV exposure that was rapidly cleared. I suspect this as your earliest test had both IgM and IgG positivity against HBV, and your anti-HBV core antibodies have persisted (IgMs come up first and then the “class switch” to IgGs, so IgMs are only around transiently right after exposure to a new antigen).

The lack of anti-HBs antibodies is a bit unusual for clearing an acute infection, but the other arm of your immune system, “cell mediated immunity” can get rid of HBV too. Regardless, you are not infected as your doctor tested for HBV DNA recently and the test was negative.

Finally, you are not immune to HBV as your anti-HBs antibodies are negative. I recommend getting vaccinated against HBV.

I wish you the best.

John.

2 Likes

Hello @Michaelmike223

My case is different since I’ve had the virus for 40 years. I suspect my fatty liver is caused from the virus but no medical professionals will confirm. Maybe they don’t know.
I strongly suggest you get vaccinated against this virus. It’s a course of 3 injections over 6 months, please Mike make this a priority. I would not wish this virus on anyone.
Now that you know that you don’t have this life long virus, but was exposed, you have missed a bullet.
Blessings Caraline

2 Likes

Thank you for the detailed response. I just find it so odd being on immunosuppressive drugs for crohns Disease that my body would’ve been able to clear this off isn’t that like unheard of? Thanks again for the response.

100% getting vaxxed thank you I was younger it didn’t stick apparently hoping for better luck! Thanks wishing you the best

Thanks for the response and the informative articles

Hi @Michaelmike223,

The human immune system is remarkably complex, so taking one type of immunosuppressant does not necessarily lead to a global down-regulation of all immune responses–it depends on what is being targeted with the immunosuppressant. As I said, it is extremely complicated!

The HBV vaccine is one of the best ever developed, but about ~5% of people do not respond adequately to it. For example, I’m a non-responder after 2 rounds of vaccination. So your treatment for Crohn’s Disease might not be the reason you did not respond adequately to the vaccine.

John.

2 Likes

Hi.
Your post was interesting to me. I found my twins. I also have the same symptoms while I had multiple negative results for STI.
I cleared acute hbv. My last hbv result was
Hbsab 1000
Hbsag negative
Hbc total negative
Hbv pcr negative

I want to give you some notices.
Drink water at least 7 glasses each day
Increase intake of fruits and vegetable particularly orange pomegranate kiwi
Eat nuts particularly walnut, almonds,…
Black seed and honey are also good.
Use this schedule for your food until several months all of your symptoms will go.

At this time how are you? Still have symptoms?

I’ve been living with hepatitis b Since 15+ years, currently my LFTs and viral load are in normal range, current viral load is 27IU and HBV DNA is positive, my question is that can it damage my liver?

Hi @Bismillah,
Good question. But with results and numbers that low, damage to the liver is less likely. That is why it is important to continue with frequent monitoring through blood work and abdominal ultrasounds. This virus can change without any warning hence the consistent and frequent monitoring. Thanks, bansah1

How much time does virus take to lift itself as ihve been suffering from it since 15+ years and current results and imaging are bormal

Hi Bismillah,
I am not sure I understand your question. If you have a chronic infection as it is in your case, the virus never goes away. It can remain inactive for many years without causing any damage in some people. It is a different story for other patients. Only a cure will help remove it but right now we don’t have a cure. Thanks, Bansah1

2 Likes

Hi,

Please share your thoughts and advice, my doctor says to go on anti viral therapy with tenofovir.
So my recent lab results, though the last one was 3 months ago,

viral load, 1 IU/mL = 1.72 copies/mL
24-nov-23 3000.000 copies/ml = 1,744,186 IU/ml
16-jul-21 150.000 copies/ml = 87,209 IU/ml
31-jan-20 57.000 copies/ml = 33,140 IU/ml

ALAT(GPT)
24-nov-23 51 U/L , normal range < 45
16-jul-21 normal range
31-jan-20 normal range

bilirubine
24-nov-23 26 umol/l, normal range < 17
16-jul-21 normal range
31-jan-20 normal range

I feel no pain, nothing.

Br,

Hi @hepb1,
You are correct about the increase in your viral load. It looks like there have been a steady increase here since 2020. Your ALT number is up a little in November 2023. If your doctor recommends it, I will go ahead and start treatment. You don’t want to wait until severe damage is done to your liver. Bringing your viral load down will certainly help. I hope this is helpful, Bansah1.

1 Like

I agree with @Bansah1’s interpretation. Your doctor feels you fall within the treatment guidelines and would benefit from therapy. Tenofovir is one of the 2 best drugs for HBV (the other is Entecavir, and the 2 drugs are essentially equally potent). Tenofovir is extremely well tolerated in almost everyone and is usually taken as 1 pill once per day (follow your doctor’s prescribed dosing pattern). Your doctor knows your case the best, and if s/he recommends starting Tenofovir, then that is a good option for you.

I wish you the best.

John.

2 Likes

Please I need better understanding of this results
HBsAg - Reactive
HBsAb - Non Reactive
HBeAg - Non Reactive
HBeAb - Reactive
HBcAb - Non reactive
Pls should I take medication. And can I spread it to my sexual partner or not?

Dear @Basheer_Sani,

Welcome to the forum and hope you get the support you need here.

These lab results are consistent with a chronic infection with Hepatitis B (assuming the HBcAb results are for IgM and the anti-HBc total antibodies are positive).

Regarding medication, the current guidelines require more tests to determine if you would be eligible for treatment. These additional tests include liver function tests (including ALT levels) to see if you have active liver injury, fibroscan to see if you have past liver injury, and HBV DNA test (PCR) to see how high your viral load is to see if antivirals would be effective.

The last test (HBV DNA PCR test) would also show how likely you are to pass it to other people (higher viral load = more risk of transmission), but the current understanding is that if you are HBsAg-positive there is a chance of transmission. You can lower the risk of infection by using barrier contraception (condoms) and ensuring your partner is vaccinated.

Hope this helps,
Thomas

Thank you so much for the information, I will try and get those tests.

@Bansah1 I meant I got myself tested for HBV DNA PCR which is 27 IUml and sgpt is 45, should I get antivirals, should I need to worry?

Hi @Bismillah,
The answer remains the same as the previous response. Your numbers are still very low and do not meet the guidelines for treatment. But It is important that you remain under care. Thanks, Bansah1.