EXPLAINER: Lab results and their interpretation

Hi I need help could you tell me what this means?
I can’t post but it’s from Quest Diagnostics it’s pre employment lab test

For hepatitis B it says

HEPATITIS B SURFACE AB, QL
Reactive

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Hi @Dabgirlie,

Positivity for Hep B Surface Antibody means you have been vaccinated (or have cleared a previous infection) and are protected against any further infections.

Hope this helps,
Thomas

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Hello.

Last year in May my HBV DNA viral load was 9540 iu/ml

On 7th of Sep 2022 my HBSAG was 795 ui/ml

Today on 29th of Sep HBV DNA is negative.

I was diagnoves with chronic hep B last year in may and have been taking Tenofovir daily.

Please how do you interpret this results?



Dear @Aleksi12,

These results indicate that your antiviral meds are suppressing the virus successfully. As you continue to take the medication, you should expect to have much lower liver disease progression/inflammation.

Hope this helps,
Thomas

After been tested positive for Hbsag, 5 months later a combo test was administered and the result is below;
Hbsag positive
Hbsab negative
Hbeag negative
Hbeab negative
Hbcab negative

Please explain plainly to me, is the results still at acute or chronic stage. Thank you.

Dear @Anasaladan,

Thank you for your question. The results suggest a chronic infection as HBsAg is detected. However, what phase you are in is difficult to determine, as it does not fit the usual profile of any of the phases. This is not dangerous for you in itself, but just not a standard presentation. Perhaps one of our @HealthExperts would be able to suggest what they would do in these cases?

Cheers,
Thomas

It is possible that the HBcAb report is reporting IgM rather than total HBcAb - worth checking what was reported .
If indeed the total (IgG) HBcAb is negative and the only marker positive is HBsAg it is very unusual and would wait perhaps 4-6 weeks and repeat all tests including HBV DNA.

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@Anasaladan I had similar profile before but I got to know that most lab technician read the combo test like PT which is incorrect. The last two markers are indirect test from what I read from a test kit manual. If the HBeAb and HBcAb T-band is negative, it means you are reactive and vice-versa.

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Hello Forum,
I was recently diagnosed with hep b…live in the States. I have been reading this forum in last 2 weeks and I learn a lot!! Thnx to the scientists and management of the forum…especially Thomas, Andrew and others…thanks for what you do!!
My results are as follows
AST 25
ALT 45
All other labs normal… ( high cholesterol)
My hep b is positive… and I am hep E antigen Negative
Anti HBE positive…
The alarming part is my AFP value is 16. I need help to understand this…
My HBV viral is 6290iu/ml

Am I considered inactive? What about treatment?
My doctor will schedule fibroscan soon…

Does alcohol contribute to AFP level?
Again thnx for your time and help

Hi

I am from India and this is regarding my father. He recently diagnosed with hep b. He had no symptoms and we suspect its chronic. We dont know how long he had it. We( myself and family (2 year old) and sisters) had been in close contact with him.
I am hep -b vaccinated. But my husband had only one dose when he was kid. My kid was in close contact with my father fro the day she was born. We vaccinated her as per norms .
Now with father being diagnosed ( he is 66 years old) we are worried about his health . we are not able to get right diagnosis here.
Here are his results
HBsAg - Positive - 6.63
ASP -199
ALT- 187
GGT-88
BILIRUBIN - 1.74
ALP-158
He is scheduled to get an ultrasound.

Can you please help me understand the results and his state. What more tests do we need to do.

And how much risk are we in as family , who are partially vaccinated.

Please help us.

Thank you
Asha

Thanks @Smart55, that is a fantastic point. @Anasaladan, It is worth getting a blood test and making sure that the results coming back are appropriately interpreted.

Dear @nass,
Welcome to the forum and thanks for asking your questions.

Your blood results are consistent with the “immune active” phase as your ALTs are elevated and HBV DNA moderately high. The fibroscan results will indicate whether you should be considered treatment or not; if there is fibrosis, then under current AASLD guidelines you should be considered treatment (happy to be corrected here, @norah.terrault).

Alcohol has been associated with increased AFP levels (https://www.tandfonline.com/doi/pdf/10.3109/00365519409088427) but I’m unsure about how common this is.

Normal AFP has been reported to be within 0-40ng/mL (though this may depend on the lab, best to look at your results and consult the normal range). These levels can also increase if you are pregnant.

Hope this helps,
Thomas

Dear @sajdale,

Sorry to hear about your circumstances and the worry that your father’s diagnosis has caused. The blood tests indicate that there is some liver inflammation happening. There are ways to reduce this (for example, antiviral treatment), but you will need to discuss this with your doctor to see what is right for him.

Simply living with someone with Hepatitis B is not a high risk of transmission. Sharing meals and other casual contact holds no risk. It is a risk if there is blood to blood transmission.

If you are successfully vaccinated, then this is complete protection. You can see if you are successfully vaccinated by getting a anti-HBs antibody test. If it is above 10, then you are considered to be protected.

Hope this helps,
Thomas

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Thanks for your immense help, does your “reactive” means I’m still in acute stage?

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Thanks Thomas
The lab range for ALT is 10-46
And my level is 45. Is it high because of value selected by AASLD?

What is you opinion about Fib-calculator and APRI accuracy and comparison to fibrosure?
Probability for results to match?

I’m 43 yr male, I believe I had this since child cause my brothers had it too…

Thnx

Apologies, I had in my mind you were female for some reason (in whom the normal ALT levels are lower). I think 45 is borderline (though various labs have different tests that have different “normal” ranges), but also depends on your baseline levels in the past.

My understanding is that Fib 4 and APRI are good for diagnosing advanced fibrosis, but don’t do so well with lower levels of fibrosis (F1-F2). I think Fibroscan is more sensitive in these cases.

TT

Thanks a lot… i reviewed my labs 2019 and my ALT was 57 and 55…I wish I tested them… due to my family history, I just decided to get tested…and this was the results. Hope my fibroscan will be fine and I be cured within next few yrs….Cure is coming!!

Is there away to donate for this forum?

Thanks

Hi all, first time posting here, my wife was just notified that there was cause for concern relating to some serology results taken through a study protocol she participated in after delivering our child (5 months ago). My wife is in her 30s and has no known history of Hep B, she was immunized according to CDC guidelines.

Here are the results from my wife’s lab:

Test Short name Result Value
Hepatitis B Surface AG HBsAg Non Reactive
Hepatitis B Surface AB, QT HBsAb, Qt Reactive 1257.0 mIU/mL
Hepatitis B Core AB TOTAL HBcAb Total Non Reactive
Hepatitis B e-Antigen n/a Non Reactive

From everything I’ve read, this indicates a healthy individual who has been vaccinated, with a normal value for HBsAb indicating the vaccination is still afffective. However, these results were flagged by our hospital and they now what to run more blood tests and have her meet with a specialist. When asked why these numbers pointed to a cause for concern, her quote:

The hepatitis serologies are very complicated and [the HBsAb result] used to be associated with immunity but are generally more specific now.

I haven’t read anything about an alternate interpretation of the HBsAb result, but it sounds it’ll be a while until we’re able to get more answers with a specialist.

Another thing she mentioned which confuses us was that this test result can often be a false positive, which is also not something I’ve seen mentioned much, and the numbers actually seem to match the expectation for a vaccinated individual. Any insight is much appreciated!

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Thomas,

I finally get FibroTest score/report from the doctor…Here is the report… this time, My ALT is high 56.
Since my HBV virus load is 6230iu/ml, AFP 16, i agreed that i am in immune active phase… due to my family history (Hep B), i feel that i need to start treatment and not to wait for Fibrosis to build up. let me know your suggestions.

Also wonder why doctor used fibrosure rather than fibroscan. Is it as accurate as fibroscan?

Thanks for your time…


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Hi Nass, if you’re in the US, you can donate to this site via the Hepatitis B foundation here: Donate » Hepatitis B Foundation. Please put down “HepBCommunity.org forum” when defining where to direct your support.

Fibrotest is a blood test that can be used to figure out if someone has fibrosis/cirrhosis or not. My understanding is that it is not as sensitive as fibroscan (which actually measure the liver physically) for milder levels of fibrosis. However, I am not up-to-date on all the latest studies on this.

I think you need to talk to your doctor about whether you are suitable for treatment. They have access to your medical history and know your situation better. There is some justification for treatment given your age, raised ALTs, and moderate level viral loads. If you have had family who have died or had cancer from HBV, then there would be strong justification for treatment.

But this is a sort of grey zone in the guidelines. Happy to be corrected by people who know better: @norah.terrault, @simone.strasser, @PLampertico.

Dear @user_j_55, thanks for sharing your story.

In the absence of anything additional factors, I would think your interpretation is correct; the blood tests don’t indicate anything other than vaccination to HBV and it being at quite highly protective levels. The HBcAb is negative, indicating no exposure either. I am not sure what the doctor’s quote means.

Thomas

Are you HBeAg positive or negative ? Country of birth ? what is the Fibrotest result? age ? gender ? family history of HCC or cirrhosis ? why do you have AFP of 16 ? what is the normal range for AFP for your lab ? What about all the other liver disease markers ? What is the final staging of liver disease according to you doctor ? mild fibrosis ? moderate fibrosis? Advanced fibrosis? cirrhosis ? comorbibities ? comedications ? BMI ?

Regards

PL

Prof. Pietro Lampertico, MD, PhD

Full Professor of Gastroenterology

Head of Gastroenterology and Hepatology Division

Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico

University of Milan

Via Francesco Sforza 35

20122- Milan

Italy

Phone +390255035432

Fax +390250320410

Email pietro.lampertico@unimi.it

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