EXPLAINER: Lab results and their interpretation

Not at but Ab. The result is Hep BE Ab Antibody reactive.

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anti-HBc IgM develops within a few weeks of exposure, but then goes away after a few months (i.e., becomes non-reactive).
Total anti-HBc levels are maintained for years after the initial infection.

Hi @jdd1982,

If your anti-HBe antibodies are detectable, then your results are consistent with you being in an “inactive carrier” phase, which is associated with less liver disease. It is still important to maintain monitoring and also find out your current liver health (e.g., with a fibroscan to measure any past liver injury)

Hope this helps,
Thomas

Am Ahmed from Ghana. Was diagnosed with chronic hep b but the doctor told me it’s non infectious. Upon running some labs he suggest I shouldn’t be on antiviral drugs. I plan to continue my education in Canada but fear this will be a hindrance.


Attached is my lab report. All advices are welcomed.

Hi @ Med,
Welcome to the platform and feel free to take some time to read/browse through some of the discussions on here. There is not enough information from your test results to provide a complete picture of your case. If you have the results for hep B surface antigen and antibody it will be helpful. The test shows that your ALT and AST are tiny bit elevated and your HBV DNA is low. If you can share those test results or get them completed it will help provide a good picture of what is going on with your situation.

Concerning your move to Canada, I am not sure they will deny you a visa because of hepatitis B given that this virus is not communicable. You can try and research this or maybe someone with information on this subject can share. Best, Bansah1.

Thanks will go for the recommended further test

Dear @Med,

Welcome to the forum and thanks for your question. While your HBV DNA levels are relatively low, any detectable levels can lead to transmission. The risk of transmission is lower the lower your levels.

You should maintain monitoring, as continually elevated ALTs would be an argument for treatment. Also, you should check your liver with a fibroscan or similar, to see if your liver is healthy or has been injured in the past.

Regarding your move to Canada, there are a few living and studying in Canada on these forums (see, Should I give up my nursing study? and Interruption in antiviral treatment after moving country). Some have moved from overseas to Canada successfully. Feel free to ask questions in those threads.

Cheers,
Thomas

@availlant or @ThomasTu or any other scientist, do we have compelling researches out there that recomend treatment even with less than CHBV DNA 1000. Are the bbenefits huge in relation to reducing HCC? I have been digging with little success. I have seen that @ThomasTu in most of his responses vouches for starting early as long as one is in consensus with his or her doctor?..there must be a rational reason and not luck?

Dear @CNN ,

With such low level HBV DNA, liver disease usually absent. However, HBV DNA integration still occurs and so the risk of developing HCC is still elevated.

This is the major philosophical difference between North American (AASLD) and European (EASL) guidelines, which advise to withhold treatment in the absence of liver disease and the newer Chinese guidelines which advise to treat any person who is HBV DNA positive.

Rates of death from HBV are not declining suggesting that the NA and EU guidelines are only partially effective in the long term management of chronic HBV and not addressing the issue of death from HCC. There is also no safety data which suggests a benefit to withholding NUC therapy in a patient with no liver disease and low HBV DNA.

This fundamental issue is what divides doctors on whether to start treatment in these kinds of patients.

Best regards,

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Hi
Thank you, founders of this community, for letting me in.I am a new member here but a hbv patient off medication for 10 years. I first got it in 2013 and I couldn’t clear the virus in 6 months. My doctor put me on lamivudine. After 4 months on this medication, l lost my hbsag and developed anti-hbs.
Now it’s been almost a decade. My test results are as follows:
Hbsag- Not detected Heb core antibody (total)- detectedHeb core antibody (igm)- not detectedHeb surface antibody- <10 IU/L
Alt- 140 u/lAST- 87 u/l
Few years after my hbv, I was diagnosed with diabetes. I saw a persistent elevation of my LFT after that.
My personal opinion is maybe the loss of anti-hbs is triggering ALT elevation coupled with the effect of diabetes.
Should I go for a viral load test? How can I lower my ALT?
I would appreciate if some experts could shed light on my test results.
Thanks in advance.

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Welcome fam.I can’t tell you much simply because I’m not an expert.Be patient they will soon attend to you @ThomasTu @availlant @ScienceExperts @HealthExperts

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Hi @Lovely,
Welcome to the platform. Your ALT/AST is high. The standard range varies by laboratory, for ALT 7-55 U/L and AST 8-48 U/L. As you can see your numbers of 140 and 87 are over the standard range. I will agree with you, but talk to your provider about this. Start from there and then if that result(s) is normal then you can probe other sources for this issue with your provider. Best, Bansah1.

Dear @Lovely,

You have no evidence of an ongoing HBV infection in this qualitative screen (HBsAg = not detected), but you do have serological evidence of a past infection (HBcAg antibody = detected; the IgM just says that the HBcAg antibody was not initially stimulated within the last month or 2). The ALT/AST values seem a bit high, but the upper limit of normal can vary from place to place and assay to assay, so you’ll need your doctor’s help to diagnose that. Loss of anti-HBs could contribute to a rise in ALT/AST if HBV were reinfecting your liver, but the lack of HBsAg in your blood makes that quite unlikely. I have no idea how this may be related to your Diabietes, but I am an HBV scientist rather than a physician.

Overall, I encourage you to speak with your doctor. S/he will be able to interpret these results in context of your full medical history and give you the guidance you seek.

I wish you the very best.

John Tavis

Dear @Lovely,

Welcome to the forum and hope you find this forum useful!

Yes, agree that your ALTs are relatively high. Given that you have been recently diagnosed with diabetes, it may be worthwhile to consider Steatotic Liver Disease (formerly known as fatty liver disease). Have a talk to your doctor about this and they should be able to do some tests to determine if this is the case.

Thomas

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Thanks so much for sharing your opinion!

Thanks @ThomasTu . I ll need to talk to a specialist

Thanks for your input :pray:

Hi all,

Could one of our lovely @ScienceExperts please help me in interpreting my results?

I had to rush on my lunch break to grab them and I didn’t want to pressure my Korean doctor to explain them quickly for me.

Previous results: all I know is I have a chronic infection but my liver function test on December showed no inflammation and normal results. My doctor did not do a full HBV DNA PCR at the time.

Also, please excuse my crusty nail, I’ve been holding out on getting them done until just before I go on vacation next week :sweat_smile:

TIA ^^


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Hi @EH1999 ,

Your liver function is normal and your HBV DNA (viral activity) is not detectable. Are you taking antiviral therapy?

Best regards,

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Thank you for you response @availlant

Sorry, not detectable? I’m not taking any antivirals, I never have. What does that mean?

Many thanks :slight_smile:

Hello, i cant read korean but does that say hbsag negative? :+1:t2:

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