EXPLAINER: Lab results and their interpretation

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#165

Dear @Jax

Welcome to the forum and thanks for your questions.

  • The antibody levels coming up means your immune system is actively fighting off the virus. This is reflected by HBV DNA going down to low levels.
  • The surface antibody is promising, suggesting that you may be on the edge of clearing the virus. It might be worth asking for a quantitative HBsAg test to see if this is going down.
  • This doesn’t mean that the liver disease is progressing. Your ALTs (a measure of active liver disease) look normal, suggesting no active liver damage. To find out whether there has been past damage, fibroscan/ultrasound should be done.

Hope this helps,
Thomas

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#166

Thank you so much for this information!

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#167

Hi everyone. If I have chronic hep b. Will HBsAg alway test positive? Or could HBsAg be negative after being on enteciver ?

#168

About 1% of chronic HBV patients per year lose HBsAg. Entecavir will not induce this, but it will not stop it either.

Thomas

#169

Thank you very much for this clear explanation.

Best,
Drew

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#170

Value
Date

HEP B DNA, PCR
841 (H)
09/21/2021

HEP B VIRAL LOAD, PCR
2.92
09/21/2021

Hepatitis B E antibody is also positive and the hepatitis B E antigen is negative.

Dealing with the diagnosis in a relationship
#171

Hi Eddie,

This is pretty consistent with what you’ve said earlier. Your HBV DNA levels are pretty low, so transmission risk is also quite low. The DNA levels are so low that under the current guidelines you would not be recommended treatment (as long as your liver function tests and ALT levels are normal too).

Hope this helps,
Thomas

#172

So that’s a good thing to know from what you saying. that’s interesting they don’t treat at that level but at that level what’s that process? the crazy thing is I got the hep b vaccine six weeks ago an then I got tested for it a few days ago being positive that would not interfere with anything right sorry for asking so many questions but I trust your answers

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#173

No problem, @Eddie. It is a lot of information to take in and totally understandable.

The threshold is 3000 IU/mL. If you are above that, then the medication has some beneficial effect. If below that, then no great improvement unless it is to slow down active liver inflammation (which can be seen by liver function tests).

Thomas

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#174

I see. so is my diagnosis way below that? Basically my rundown as what I sent you and I have a positive core anti-body an hbeag negative an hbe anti body positive does this favor me in the long run

#175

Yes, correct. People with results like yours have a better prognosis and are less likely to progress in their liver disease (there are discussions in other threads about this, e.g. EXPLAINER: Lab results and their interpretation - #158 by Drew_rous).

Thomas

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#176

Wow those HB E Antibodies being positive an HB E Antigen negative seems they play a very good role so that being said I should not worry so much it seems like I just take care of my self get my check ups my life should be good

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#177

Had a question I was reading that you can lose your hepatitis B E antigen antibodies I don’t think that’s true but just wanna make sure with you

#178

It is possible (for example, if you become immunocompromised), but it is fairly uncommon to lose Anti-HBe antibodies.

Thomas

#179

I see thanks for the reply I have test coming up in the next six months but didn’t see a hbsag test or hbssg test of what the load is I see people have gotten that I live in the states is that something that needs to be checked or is called something different where I’m at for that type of test

#180

So the discussion we talked about were talking about the same thing right? about the HBeag being negative and HBeab positive not about Hbsag hbsab right because that link doesn’t talk about Hbeag an Hbeab Just making sure what you said is right I do have advantages because of my HBeag- an Hbeab+
that gives me a better prognosis and led progression to any liver disease just to clarify

#181

Yes, the advantage is from being anti-HBe positive and HBeAg-negative. Sorry, I included the wrong link. I meant this one: EXPLAINER: Lab results and their interpretation - #158 by Drew_rous.

Thomas

#182

Thanx Thomas for the reply if it is not too much to ask I live in the states and when they sent me my results my dna load is 841(h) an my viral load is 2.92 can you break this down for me to understand?

#183

Yes, 841 means that the approximate number of viruses per mL of blood. 2.92 is just another way of expressing the value (841 = 10 to the power of 2.92).

Thomas

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#184

So correct me if I’m wrong so that means out of being under the 2000 copies and US standards of treatment I’m only 841 copies pretty much from 2000 or viral load?