Diabetes and HBV

If you have type 1 diabetes but really well maintained a1c is 5.5 glucose always under a 100 how bad is that to have with hep b?

Hi Eddie,

Great that you have your T1D under control. I know type 2 diabetes can have major impacts on hep B and increase the risk of liver disease, but unsure about type 1. Perhaps some @HealthExperts could chime in here? @simone.strasser @MarkDouglas @PLampertico?


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Hi Eddie,
As Thomas said the main risk is with type 2 diabetes, as this is commonly associated with fatty liver disease. Metabolic dysfunction associated fatty liver disease (MAFLD) is present in over 50% of people with type 2 diabetes and metabolic syndrome and can cause inflammation in the liver. This can cause worse liver disease in someone with inflammation in the liver from both untreated hepatitis B and fatty liver disease.
In people with type 1 diabetes this association is less common, although I believe up to 50% of people with type 1 diabetes can also have MAFLD, particularly if they are overweight.
So the main thing is to keep your diabetes under good control and maintain a healthy weight and lifestyle.
In that case there should not be much impact on your liver, although of course it is important to monitor your liver and treat the hepatitis B if your doctor recommends it.
Mark Douglas (Infectious Diseases and Hepatitis specialist)


I agree, to my knowledge there are no robust studies linking T1D to HBV outcomes

Prof. Pietro Lampertico, MD, PhD

Full Professor of Gastroenterology

Head of Gastroenterology and Hepatology Division

Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico

University of Milan

Via Francesco Sforza 35

20122- Milan


Phone +390255035432

Fax +390250320410

Email pietro.lampertico@unimi.it

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