Hi @nawab
This is quite an interesting result, but as always with early studies, caution is warranted.
The biggest 2 things in my eyes is that there is no obvious reason why cccDNA should have gone down that far in the patients that responded best, and that biopsies are great for telling us what’s going on in that little piece of the liver but can miss things elsewhere in the liver.
I am quite excited about the results because they provide even more evidence that the “half-life” (ie, time it takes half of the cccDNA to degrade) is shorter than we had believed for decades. Shorter halflives means it will be easier to cure HBV!
So let’s be cautiously optimistic and keep our eyes on this.
John.
Dear @john.tavis, indeed, the results are interesting but the duration of taking peg-interferon for 48 weeks is scary esp given to its side effects.