Can HBV DNA become undetected without medication?

Hello everyone,

In august 2024, I went for check up and the results are:

DNA: 317 iu/ml, normal liver function, hbeag negative and hbeab positive. I wasn’t placed on medication because it was too low.

so, after I was sacked at work because of my hbv status, I went for another check up in January 2026. Results have been attached below.

I was also told to do the titre test for my son, I have been scared to do the hbsag test for him, result below too.

Kindly help me interpret them. @ThomasTu @Bansah1 @Caraline and others

Hi @Flo,
From the labs, your HBV DNA is undetectable, which is even better given that you are not on treatment. Additionally, there is no evidence of viral replication, which is positive news. Overall, your labs indicate a well-controlled disease.

According to the results, your son has developed antibodies against HBV. He has a strong level of protection. I hope that is helpful to know because you were concerned about that.I hope this is helpful. Best, Bansah1

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Thank you @Bansah1 I want to know if people have seen cases of people who became undetectable after being detectable before, in my case (317) without medication or treatment.

In my LFT the direct bilirubin is 0.5 meanwhile the range is from 0-0.4, that’s a bother to me. Also, my CBC (the white paper on the pink report) I have results that are marked with L or H, what’s their implication? That bothers me too.

My husband is still negative and he has finally started taking vaccines. His third dose is today.

Lastly, with my son’s report, does it mean he’d definitely be HBsag negative?

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Hi @Flo,
Yes, that is possible in some patients. It means your immune system has been able to control the virus without the need for medication. This is good, and continue to keep an eye on it.

0.4 and 0.5 are that close, I will keep an eye on it, but not worry too much about it. It is challenging to interpret the other results because they are not clear enough to see; however, I recommend consulting with your doctor if you have any concerns about those.

It is great to hear that your husband is almost through with his vaccination. He can check his antibodies in a couple of months to see whether he developed any. With your son, he has strong antibodies against hepatitis B, so no, he will not be infected if exposed to HBV. Yes, the HBsAg should be negative. Your son has a strong level of antibodies. You can retest again in 10 years, not required, but it will give you peace of mind and ensure those antibody levels remain high and strong.

I hope this helps. Keep up with what you are doing because it is working. Bansah1

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Hi Flo

Just wanted to check if you were hep b positive while you were pregnant, if so did your son receive immunoglobulin and 3 shots of hep b vaccine

Thank you @Bansah1 the information really helped. I’ll keep an eye on it. I get tested mostly every 12-16 months. Hopefully my immune system continues to do well. I will see my gastro next week too.

I am so happy about my son’s report, tit helped a lot with my worries and guilt I was feeling.

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Yes, I discovered my HBV status while I was pregnant. He took be immunoglobulin around 10hours after birth. First dose of the vaccine wasn’t until 5 days after and he completed his doses.

Hello again @Bansah1 @ThomasTu I am heart broken right now. I did my abdomen and pelvic scan now and it’s not looking good.

Please what happens from here? How bad is the situation considering my earlier reports that I did around 2-3 weeks ago? Who has experienced this?

@availlant @rgish @Caraline

Hi @Flo,

I’m not sure how to interpret the ultrasound results. Maybe some of our @HealthExperts could help? It is definitely possible to reach undetectable HBV DNA without treatment, and I agree that appears to be a good thing.

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Hi @Flo,
I am sorry to see your results. While it might look scary and troubling, please take a deep breath and try to calm yourself down. I am not an expert in interpreting imaging results. I encourage you to schedule an appointment to see the doctor who ordered this test and discuss the results. They might be in a better position to provide more information and guidance on this matter.

Please let us know how that goes and what they say about this issue. Fingers crossed, and let’s remain hopeful in hearing something more positive about this matter. Thanks, Bansah1

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Hi @ Flo

Your currently HBV status is HBeAg negative immune control ( true inactive carrier). According to your concern about Ultrasound finding results , I have consulted with radiologist (my wife) . She said that small amounts of fluid in POD

(pouch of Douglas) in women with reproductive age detected by ultrasound is usually normal due to follicular rupture during ovulation making fluid releases or may be from shedding of uterine mucosa during menstrual flow resulting in fluid collection in POD.Your liver is not inflamed as your ALT looks normal (<= 19 IU/ml in women) . I hope this may help you to understand about your conditions.

chul_chan

Chulapong Chanta. MD. Pediatrics.

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Thank you for taking your time to read.

I am not even bothered about the POD, what I’m bothered about is the inflamed liver, considering the fact that my LFT is normal and my HBV dna is undetectable.

Are these combinations normal?

@chul_chan

Hi @ Flo

Your concern about “starry sky appearance” of the liver from ultrasound findings which is nonspecific sign and may be found by various etiologies eg : hepatitis, fatty liver. Radiologist interpret from the picture of ultrasound findings, however in clinical practice, most clinicians use clinical data and laboratory findings for diagnosis.From your normal AST and ALT , it is less likely for you to have inflamed liver.You should consult with your doctor to find out for other etiologies such as fatty liver which is common in general population.You may self assessment with your BMI , waist circumference and height ratio which is simple physical index that help in diagnosing abdominal obesity (fatty liver) . I hope this may help you.

chul_chan

Chulapong Chanta. MD. Pediatrics.

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