J’ai plusieurs questions concernant l’antigene HBS.
J’ai decouvert mon hepatite B en 2010 durant ma grossesse, j’avais une charge virale de 8000 ui et un antigene HBS d’environ 50 000 ui. En 2019 l’hepatologue m’a mise sous entecavir car le fibroscan etait à 7 hpa et j’avais des symptômes divers. Aujourd’hui mon adn est indetectable mais mon antigène HBS ne diminue pas et reste environ à 50 000Ui. Et j’ai développé une fybromialigie secondaire.
Mes questions sont les suivantes:
-Que signifie un antigene HBS élevé ?
-Est ce plus grave pour le foie ?
-Peut il diminuer sous entecavir ?
-il y a t’il des traitements en développement repondant à un antigene HBS élevé ?
-J’ai le genotype A, est il de bon pronostique ?
-Ma ferritine est tres basse ainsi que mes globules blancs et VGM élevé, est ce lié au traitement ?
Hi, I am not an expert or doctor. I will answer some of your questions:. Entecavir will not directly decrease your serum HBsAg (however, some believe prolonged treatment with Entecavir may need to a natural decrease of cccDNA in the liver and a resulting decrease in serum HBsAg). Serum HBsAg is not harmful, as it is just a protein, is not infectious, however it will prevent your own immune system from clearing the HBV virus. Genotype A is the best HBV genotype to have, and genotype A HBV is very amenable to Interferon treatment. There is a company in Quebec, the French part of Canada, Replicor (replicor.com) that develops drugs to very substantially reduce serum HBsAg. You can visit its website to find out all about HBsAg. Also, its Chief Scientific Officer, Dr Andrew Vaillant is an expert here on the forum and he can certainly answer your questions.
Cheers.
Bonjour, merci beaucoup pour votre reponse. C’est tres intersssant et important pour moi d’avoir des reponses aux questions que je me pose.
En effet, j’ai l’impression qu’avec mon niveau élevé d’antigene HBS je ne pourrai jamais guerir et que les nouveaux traitements en cours de developpement ne repondent pas à mon profil.
BIen cordialement,
Marie
Thank you for your questions and I will try to answer them as best as I can:
1 and 2- High HBsAg is common in many people with Hepatitis B. It means many of your liver cells have the virus in them, which means it is harder to get rid of. This level does not have anything to do with the health of your liver though.
3 - As mentioned in my previous Email, entecavir does not affect HBs antigen levels, but it does stop new virus from being produced. This helps stop liver disease progression and liver cancer.
4 - There are clinical trials underway developed to treat people with high HBs antigen levels, but more testing needs to be done.
5 - In the general case, Genotype A is associated with better outcomes and higher likelihood of clearance compared to other genotypes. We don’t fully understand why.
6 - These lab results could be due to many different causes and it is best to go to your doctor about understanding the cause of this. It is however not a common outcome of antiviral treatment.