New liver cells from replication (=mitosis) doesn't contain cccDNA

Both great points and definitely issues that need to be really well investigated before wide-spread use.

Dear @lemlem, great question. We know that even with natural clearance of HBV (acute infection), people still have active cccDNA in their liver. This is generally well suppressed by our immune system, but the infection can reactivate if you are put on very strong immunosuppressants that affect B-cells (the producers of antibodies).

Thomas

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