New Drugs to cure Hep B?

If we can get a functional cure for chronic hbv is going to be a very long help…
But sir when someone gets a functional cure for hbv ,will the person still test positive for hepatitis b surface antibodies

Dear @chigoziekingsley5454,

Production of anti-HBs antibodies is not tied to functional cure. Many people who have achieved functional cure do not have detectable anti-HBs. This does not mean that they do not have an anti-HBsAg response in their immune function, just that we do not see antibodies like in vaccinated individuals.

@availlant

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Hello, I have been positive for hepatitis B for more than 20 years and now I am presenting with liver cirrhosis. What would be the best treatment for me?

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Dear @Isuzo,

I am sorry to hear of your cirrhosis diagnosis. Cirrhotic HBV patients can have a wide variety of clinical issues that impact treatment options, so I strongly encourage you to see a hepatologist for the medical guidance you seek. S/He will have access to your full medical data and the training to guide you to what is best for you.

I wish you the very best.

John.

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My current lab results:
• ALT: 44
• AST: 22
• Total Bilirubin: 1.9 mg/dL
• HBV-DNA: ~1300–1500 IU/mL (5–6 months ago)
• Liver ultrasound (10–12 months ago): normal, F0
• No antiviral therapy

Iron panel:
• Serum Iron: 217 µg/dL
• UIBC: 42 µg/dL
• TIBC: 259 µg/dL
• Transferrin Saturation: 84%
• Ferritin: 55 ng/mL

Hello everyone, I truly need your support.

Until recently, I was just beginning to come to terms with my chronic hepatitis B and started monitoring it more carefully.
Then I got hit with something unexpected — a high iron panel, especially transferrin saturation at 84%. This was my first-ever iron test, so I have no previous values to compare.

I haven’t seen a doctor yet (my appointment is in 2 weeks), and I haven’t done a genetic test for hemochromatosis yet.
But these results have pushed me into deep anxiety and even depression. I’m 32, and I keep thinking this adds a massive new risk to my liver and health overall. I’m overwhelmed and afraid that my chances for a long life are now much lower.

It’s been 3 weeks since I’ve started trying to limit iron in my diet. I’ve lost weight due to stress and fear of eating anything “wrong.”
I’m the kind of person who takes every abnormal result very hard, and this has really shaken me.

Please, if anyone has experience with iron overload and hepatitis B — or has faced something similar — I would be incredibly grateful to hear from you.
• How dangerous is this combination?
• Can both conditions be managed safely in the long term?
• Does this drastically reduce life expectancy?
• How serious is this situation really?

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Has anyone heard of this drug? It does not seek to cure but rather to reduce and prevent fibrosis. If it is in fact effective, it can help us a lot, friends. It is good form to keep ourselves informed about this research already in phase 3.

https://ir.gyretx.com/news-releases/news-release-details/gyre-therapeutics-hydronidone-met-primary-endpoint-and/

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