Intereferon Hep-D

How often to check the LFTs while being on Intereferon.

If there is little flare of the LFTs like jump from 45 to 65, does it indicate a good sign or its too small

@availlant @ThomasTu @Joan_Block

Dear Suresh,

Testing intervals < 6 months apart and preferably < 1 month apart are better to capture ALT flares and their maxima. Clinical data from pegIFN or pegIFN + NAPs has shown that the stronger the flare, the more likely HBsAg loss (and functional cure) will occur. These ALT flares are typically > 10X the upper limit of normal.

I would be encouraged by any ALT flare (which is host mediated) but minor elevations like the ones you are describing are not associated with HBsAg loss.

Hope this helps.