Hi @Limin ,
Switching from TAF to TDF or even ETV shouldn’t cause an issue when looking from an antiviral treatment standpoint. My hepatologist had me switch amongst all 3 within the span of a year to see if any particular one would cause less side-effects. The only reason I can think of based on information from this community is TAF is easier on your kidneys if you have kidney issues. TAF has less chance of potential osteopenia (bone degeneration) and osteoporosis. Also, TAF has less dosage of medication. I think I got that all correct. I believe that the majority of people on TDF don’t experience those issues significantly. Plus, you are young and when you are finished with schooling, if you decide to stay in the U.K. afterward, maybe TAF will go off patent by then. Or, maybe when you are finished with schooling, you will move elsewhere, where TAF is available.
Finally, I agree with Levi, I don’t believe switching to U.K. time would be harmful. There are days that most all of us have missed a day’s dose. I have even taken my daily pills twice by forgetting what day it was (even though I have a weekly pill box). I would suggest changing to U.K. time since you are moving there and not just visiting for a vacation. I am pretty sure that your body will acclimate to the time change of when you take your meds based on your new schedule.
As always, I am no expert. I am just relaying my opinion based on the little I know and the accumulation of vast amounts of knowledge from this community. One of the experts will confirm or correct this advice. For now, I hope it allays your worries some.
What a big move this is in your life, you must be excited and probably a little bit anxious. I believe you will do well and prosper and you have this community wishing the best for you!