EXPLAINER: Lab results and their interpretation

I have never been on any treatment yet, is this “Seroconversion of Hepatitis B”? HBeAg is undetectable 0.04 and Anti-HBe Reactive at 4.5 (report bio. ref. says greater than 1.2 is Reactive)

Dear @Ankap,

As mentioned in the messages above in this thread, HBe antibody results show that your immune system is active against the virus and that your virus levels are probably low. You would have to confirm this with a HBV DNA test.

People with HBeAg-negative anti-HBe-positive with no active liver damage (such as you are) generally have a lower risk of liver disease. This is good news for you, but you need to check out your liver properly by going to the doctor and getting assessed appropriately.

Hope that clears things up,

Hi Thomas,

What is the possibility of HBsAg clearance in this case. Is he has chance to clear it with/without medication.

Generally, people with chronic Hep B have about a 1% chance a year to clear HBsAg. We still don’t understand what the reasons are. But this is definitely under a lot of scientific investigation because if we find out how the body does it then maybe we can help it along with some therapeutics.


Thank you for response, will surely check this with doctor and further with more tests.

Waiting for permanent cure soon.

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Good day to the admins and everyone,thanks for always attending to us. I am 35yrs old male.
Below are my test results for another 3 months checkup after starting tdf since February. My Alt dropped from 42 back to 37.

I have some really major concerns which I am not getting answers to,even my gastroenterologist/hepatologist not giving an adequate answer to my problems. Please i really need help as I am not doing well mentally with this.i started tdf in February,with dna of 7124,normal ultrasound and lft.Major concern was tiredness and body pain then,platelets 231 and weight of 58kg. 3 months after starting tdf my weight dropped to 54kg,platelet dropped to 221. Normal lft except raised alt to 42.i developed serious body itching and skin writing.fibroscan of 4.6kpa, vitd3 level of 18.

My gastroenterologist said she doesn’t know what could cause the itching,but I suggested maybe tdf caused it. About weight loss she just said eat well ,which I have always been doing. Plus I get clicking joint sounds. I am supposed to see her this month since last 3 months checkup making it 6 months starting tdf,but to my surprise on the new test results my platelets dropped to 144 from 221,althiugh lft normalised, weight dropped to 50kg. AFP 2.8 from 2.2 before tdf.Normal ultrasound. My appointment is in a weeks time but I am worried why I am losing so much weight,people are starting to ask questions why i am reducing so much. I started taking vitd3 with k2.

I am losing my mind,scared and worried. Is the tdf draining me this much?why could be reducing the platelets like that and weight. My knees,arms,chest all are bony with reduction in size.lastly dna is undetectable.thank you as you respond to me.

@john.tavis @ThomasTu

In case you missed this post. What is your advise and opinion on it ?

Thanks for the reminder @HopeForCure,

@Davhope, the lowering ALT is a good sign that the antivirals are working, but the weight loss would be quite a concern and I’m sorry to hear about this. It really should be something you raise with your doctor as it is difficult to advise over the internet regarding whether this is the medication or something else that is contributing to these changes.

If it is the tdf, others have experienced improvements after switching to entecavir or taf. This may be an option you could consider.


Hi @HopeForCure,

I’m a basic/translational scientist and cannot give medical advice. With the understanding that this is not a medical opinion but thoughts from a lab researcher:

It appears as if TDF is working to help normalize liver function, so the concerns appear to be unexplained weight loss and lowering platelets. Many things can cause such symptoms other than liver issues, so you may wish to see a general practitioner rather than a hepatologist to do a top-to-bottom diagnostic assessment. Without a full workup, I would do you a serious disservice by speculating on what might be causing it.

I wish you the very best,

John Tavis

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Dear @HopeFor Cure, I agree with Dr. Tavis that you really need to see your primary care doctor to find out why you’re losing so much weight? This is not a known side effect of TDF or any hep b antiviral. So something else is going on. As far as the decreasing platelets, that’s something your GI/hepatologist should be following closely. We all encourage you to be persistent and get answers to your valid questions. Thanks so much for sharing your concerns with us. Always, Joan

Hi Davhope,

After I started Vemlidy (TAF) in 2017, I had weight loss issues. I had averaged about 185 most of my adult life. Sometimes more, sometimes less within about 10 pounds. Within the first few months of being on Vemlidy, I dropped 40 pounds and even hit 138 at one point and had to go to the ER. I was having major digestive issues and was not eating a lot because I would have so much pain. There were a lot of other issues but this is a pretty isolated incident that you don’t hear from many other contributors on here. My doctors are still trying to figure out why I have so much bad reaction to the meds they give me. For most people, there are little to no side-effects from antivirals. I didn’t start treatment until I had already been in the cirrhosis stage for some time.

So no explanation, I just know that I had this issue in a major way with weight loss. Over a couple of years, I started to increase though, and now I am at a respectable 160 average. Muscle loss was a big issue too. I have noticed that I am starting to build some muscle back as I used to be pretty muscled before I started any treatments.


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A post was merged into an existing topic: Deciding when to start treatment


I was diagnosed with Chronic HepB 3 months ago and since then have made a lot of changes to my lifestyle which have been very helpful.

Recently, I caught seasonal flu (most probably Influenza A as it was spreading in my area but I was unable to get it checked). My hepatologist happens to live in another country so I was able to connect with her only by phone. My GP here who is aware of my condition ordered Liver Function here and the ALT (55) levels were a higher than usual (30) although not alarming. I had done COVID test also which came out negative and all other markers for bacterial or parasitic infection like Typhoid, Dengue, and Malaria were negative. Monocytes were at 10% which indicated some infection according to the doctor. My GP wasn’t very worried about the elevated levels. According to him it is general to have slightly elevated ALT incase of viral infections.

I have recovered from the infection and my Liver tests are due in December. Should I be worried about the elevated levels of ALT or they would have normalised since the infection went away?

Anyways, I am planning to get flu shots regularly now as I am told chronic hepatitis b carriers should take more precautions.


Dear @CGNepal,

Thanks for the question and sorry to hear that you are sick with the flu. There are some reports out there that the flu can either increase ALTs or stimulate the antiviral immune system to start attacking virus infected cells in your liver.

My feeling is that it would be that it would be more accurate to see what your ALTs are like after you have cleared the flu to see how your liver is going during a more “normal” circumstance. Probably someone like @Suwang88, @simone.strasser or @MarkDouglas could give a better answer with their clinical experiences.


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Yes ALT can go up a bit with a range of viral illnesses so no need for alarm.

Repeat LFTs once you are well and discuss with your doctor from there.


Thanks @MarkDouglas and @ThomasTu :slight_smile:

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My viral load count was around 87 million iu/ml in march 2021. I was put on Tenofovir but I felt so sick after a month of taking it. My doctor switched me to interferon alpha 2a. After 11 weeks of interferon injections, I repeated my labs last week with the following reulsts;

Because I was waiting for the viral load results which took more than a week to come back, I’m 9 days late with the interferon injection.

  1. Will the interferon still work if I continue with it considering the fact that I’m 9 days late?

  2. Is there a possibility of me clearing the virus?


Dear @Listowel,

Looks like the therapy is quite effective on your viral loads; they’re down to below the limit of quantification. There is always a chance that you could clear the infection, though the probability varies from person to person (we are not completely sure why).

Regarding interferon treatment interruptions, I’m not sure. Maybe @MarkDouglas, @PLampertico or @simone.strasser could comment.


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Thank you for your continued support.

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Is it possible to have HBeAg and HBeAb all non reactive in chronic hepatitis B?

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