Does this mean a partial cure?

Functional cure or very early suppression of HBV DNA to < 10 IU/mL will be the best. In these scenarios there will be negligible production of (erroneous) linear HBV DNA, which is the form that becomes integrated into host chromosomes and causes DNA damage to the host cell.



Agreed, and now that I think about it, I’m not sure it was powered to detect differences in the patients with low rates of cancer (such as those below 2000) - so even if there is an effect, we may not know just because of probability.

One study of 20,000 people is here: HBsAg seroclearance further reduces hepatocellular carcinoma risk after complete viral suppression with nucleos(t)ide analogues - ScienceDirect

Compared to complete viral suppression, lack of complete viral suppression was associated with a higher risk of HCC (7.8% vs. 5.6% at 8 years, Gray’s test, p <0.001) (adjusted hazard ratio [aHR] 1.69; 95% CI 1.36–2.09; p <0.001); patients who achieved functional cure had a lower risk of HCC (0.6% vs. 5.6% at 8 years, Gray’s test, p <0.001) (aHR 0.24; 95% CI 0.06–0.97; p = 0.045) …

Hope this helps,