Hi guys,
New member here. I am so grateful to have found such a wonderful community and appreciate all the contributors here, whether the experts or fellow patients.
I donāt know where to start a new topic so I will seek opinions here. Long winded post, sorry
Background:
Iām 40y Chinese male from Malaysia. I was diagnosed CHB (HbeAg-) in 2014 at age 30. Later found out my mother is & my late grandmother was CHB so most likely thatās the cause of infection. Grandmother died from stroke at age 80+ but her brother (who was also CHB) died from HCC at age 40+.
I have been monitored regularly since 2022 in a public hepatology center. Occasionally get ultrasound screenings from my family doctor (who urged me to get monitored) if the appointments with hepato are over 6 months. I have not started any treatment.
Some quick stats:
HBV DNA:
18 Oct 2021 - 4632 IU/mL (first-ever HBV DNA test)
11 Oct 2023 - 739 IU/mL
Fibroscan:
11 Oct 2023: 5.3 kPa / 0.6 / CAP score 211 (no fibrosis, no steatosis)
ALT:
Always hovers around 14-20, latest result (14 Mar 2024) - 25.2 U/L (slightly higher)
AFP:
Always @ 2.0 or below, latest result (14 Mar 2024) - 2.0 ng/ml
Imaging tests (a few ultrasounds & a 4 phase contrasted CT):
Multiple lesions were found. Details follow.
24 Apr 2022 - First ultrasound with family doctor. Found a lesion measuring 1cm x 0.8cm at segment IV. He said hemangioma.
27 Jan 2023 - Second ultrasound with him found another lesion measuring 0.7cm x 0.6cm at segment VII. Again, he said hemangioma.
11 Oct 2023 - Ultrasound at hepato. Findings as below:
The liver has normal echogenicity with smooth margins. Liver span measures 12.6cm in right midclavicular line. Multiple subcentimeter hyperechoic lesions seen at segment II, IV and VII. Largest at segment VI measuring 0.9 x 0.9 cm (I guessed she had a typo here - should be segment IV?). No intralesional vascularity.
Impression: Multiple hyperechoic lesions may represent regenerative nodules. Suggest AFP correlation, KIV contrasted CT scan if AFP high.
14 Mar 2024 - CT scans at hepato despite low AFP @ 2.0. Findings as below:
Liver is homogenous and has smooth outline. There are several ill defined non enhancing hypodense liver lesions scattered in both liver lobes, at segment II, IVa, V, VI and VI. Largest at segment IVa measuring 0.8cm in diameter. No focal enhancing liver lesion.
Impression: Non enhancing liver lesions in both liver lobes may represent regenerative nodules.
So my questions are:
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Hepatologist told me regenerative nodules happen when you have fibrosis/cirrhosis which I have none according to my Fibroscan. He was kind of disagree with radiologist to characterize the lesions as regen nodules but he has no conclusion of what they are. But he does not seem too concerned either. What can the lesions potentially be or can a non-cirrhotic liver have regenerative nodules from past damage?
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Are the so-called regenerative nodules potentially cancerous?
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How can a HCC history of an extended family member (in this case my granduncle) affect my own risk or only first-degree relatives matter?
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Does the fluctuation of HBV DNA mean anything when someone is in inactive carrier phase without the evidence of fibrosis &or elevated ALT? Is it kind of normal when not treated?
Thank you so much for your time to read through.
Regards
Steve