Hi @Vlad
Its interesting common cold-HBV beneficial scenario to come across but it do happens in several disease interplays
I do agree with Thomas, John and Tibor, that this is likely type 1 interferon driven HBV viral load suppression.
Common cold viruses like rhinoviruses and coronaviruses, are powerful activators of natural immune sensor proteins like Toll-like receptor 7 (TLR7). These natural immune responses-trigger promotes the release of type I interferons (IFN-α/β) as Thomas explained. These interferons circulate in the blood and can exercise antiviral effects beyond your respiratory tract, including in your liver.
Well, HBV is equally sensitive to interferon activation pathways, and this is the basis of pegylated IFN-α therapy for chronic HBV patients. So, your coincidental infection with common cold turned beneficial in chronic HBV infection is probably due to the induced interferon surge and this temporarily suppressed HBV replication, thereby lowering HBV DNA and HBsAg levels. This suggests that the abnormality caused by chronic HBV infection in our immune system to work poorly is rather temporary and its basis for emerging therapies such as 1L2 cytokine therapy and TLR7 triggers.
Taking plenty of fluids, eating fruits and taking vitamin C could have also boasted your immunity.
The elevated gamma globulin and total protein levels observed after your common cold is most likely due to temporary or short-term immune response from multiple B cells families.
It would be interesting to see how durable this HBV viral load suppression is in your subsequent check ups.
Good luck
Tom Adomati